Topical sodium alendronate combined or not with photodynamic therapy as an adjunct to scaling and root planing: Histochemical and immunohistochemical study in rats

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Autor(es): dc.contributorUniv Western Sao Paulo-
Autor(es): dc.contributorUniv Fed Pelotas-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorSantinoni, Carolina S.-
Autor(es): dc.creatorSilveira, Felipe M.-
Autor(es): dc.creatorCaldeira, Marcela L.-
Autor(es): dc.creatorGenaro, Vitor-
Autor(es): dc.creatorMartins, Thiago M.-
Autor(es): dc.creatorAmaral, Caril C. F. do-
Autor(es): dc.creatorMaia, Luciana P.-
Autor(es): dc.creatorMori, Graziela G.-
Autor(es): dc.creatorErvolino, Edilson [UNESP]-
Autor(es): dc.creatorPola, Natalia M.-
Data de aceite: dc.date.accessioned2022-02-22T00:11:10Z-
Data de disponibilização: dc.date.available2022-02-22T00:11:10Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-07-09-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/jre.12777-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/197052-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/197052-
Descrição: dc.descriptionObjective The purpose of this study was to evaluate influence of topical sodium alendronate (ALN), photodynamic therapy (aPDT), or a combination thereof as adjuvant to scaling and root planing (SRP) in the treatment of experimental periodontitis in rats. Background Therapeutic protocols to control periodontitis progression that aim to equalize bacterial action and load with tissue immune response are well addressed in current scientific research. Methods Experimental periodontitis was induced in 96 rats with a ligature around the mandibular left first molar. After 7 days, ligature was removed and animals were treated according to the following experimental groups (n = 8): control-SRP plus saline solution; ALN-SRP plus ALN; aPDT-SRP plus methylene blue irrigation, followed by low-level laser therapy (LLLT); and ALN/aPDT-SRP plus ALN and methylene blue irrigation followed by LLLT. The animals were euthanized at 7, 15, and 30 days after treatments. Collagen maturation (picrosirius red staining) and immunohistochemical analyses (TRAP, RANKL and osteoprotegerin [OPG]) were performed. Data were submitted to statistical analysis (P < .05). Results At 7 days, group ALN presented a significantly higher number of TRAP-positive cells and percentage of immature collagen fibers than group ALN/aPDT, while group ALN/aPDT presented a significantly higher percentage of mature collagen fibers than group ALN. At 30 days, group ALN presented significantly lower percentage of immature collagen fibers and higher percentage of mature collagen fibers than control. Conclusion It can be concluded that topical use of ALN coadjutant to SRP, alone or combined with aPDT, enhanced collagen maturation and reduced osteoclastogenesis during the healing of experimental periodontitis.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniversity of Western Sao Paulo-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionUniv Western Sao Paulo, Dent Sch Presidente Prudente, Grad Program Dent GPD Masters Degree, Presidente Prudente, Brazil-
Descrição: dc.descriptionUniv Fed Pelotas, Grad Program Dent, Pelotas, RS, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dent Sch Aracatuba, Dept Basic Sci, Aracatuba, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dent Sch Aracatuba, Dept Basic Sci, Aracatuba, Brazil-
Descrição: dc.descriptionFAPESP: 2016/04163-0-
Descrição: dc.descriptionUniversity of Western Sao Paulo: 3080-
Descrição: dc.descriptionUniversity of Western Sao Paulo: 3771-
Formato: dc.format9-
Idioma: dc.languageen-
Publicador: dc.publisherWiley-Blackwell-
Relação: dc.relationJournal Of Periodontal Research-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectcollagen-
Palavras-chave: dc.subjectosteoclast-
Palavras-chave: dc.subjectperiodontal therapy-
Palavras-chave: dc.subjectphotochemotherapy-
Título: dc.titleTopical sodium alendronate combined or not with photodynamic therapy as an adjunct to scaling and root planing: Histochemical and immunohistochemical study in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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