Different measures of HMGB1 location in cancer immunology

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniv Pittsburgh-
Autor(es): dc.contributorGeorge Mason Univ-
Autor(es): dc.creatorGorgulho, Carolina Mendonca [UNESP]-
Autor(es): dc.creatorMurthy, Pranav-
Autor(es): dc.creatorLiotta, Lance-
Autor(es): dc.creatorEspina, Virginia-
Autor(es): dc.creatorLotze, Michael T.-
Autor(es): dc.creatorGalluzzi, L.-
Autor(es): dc.creatorRudqvist, N. P.-
Data de aceite: dc.date.accessioned2022-02-22T00:10:56Z-
Data de disponibilização: dc.date.available2022-02-22T00:10:56Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2019-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/bs.mie.2019.10.011-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196964-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196964-
Descrição: dc.descriptionHMGB1 is the most abundant non-histone nuclear protein. It regulates transcriptional access to open areas of chromatin and limits release of DNA with apoptotic death, serving to both inhibit apoptosis and promote DNA repair. When HMGB1 is translocated to the cytosol with many types of cellular stress, it is a powerful inducer of autophagy. It can also be released by activated immune cells and damaged or dying cells into the extracellular space, where it acts as a damage associated molecular pattern (DAMP) molecule, contributing to the pathogenesis and progression of cancer. Here, the most common methodologies to not only measure HMGB1 but also to effectively determine its subcellular localization, which dictates many of HMGB1's different functions, are reviewed.-
Descrição: dc.descriptionSao Paulo State Univ, Botucatu Inst Biosci, Dept Microbiol & Immunol, Tumor Immunol Lab, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Pittsburgh, Dept Surg, Pittsburgh, PA 15260 USA-
Descrição: dc.descriptionGeorge Mason Univ, Ctr Appl Prote & Mol Med, Manassas, VA USA-
Descrição: dc.descriptionUniv Pittsburgh, Dept Immunol, Pittsburgh, PA 15260 USA-
Descrição: dc.descriptionUniv Pittsburgh, Dept Bioengn, Pittsburgh, PA 15260 USA-
Descrição: dc.descriptionSao Paulo State Univ, Botucatu Inst Biosci, Dept Microbiol & Immunol, Tumor Immunol Lab, Botucatu, SP, Brazil-
Formato: dc.format195-217-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationTumor Immunology And Immunotherapy - Molecular Methods-
???dc.source???: dc.sourceWeb of Science-
Título: dc.titleDifferent measures of HMGB1 location in cancer immunology-
Aparece nas coleções:Repositório Institucional - Unesp

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