The Treatment of Prednisone in Mild Diabetic Rats: Biochemical Parameters and Cell Response

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.creatorMachado, Mariana P. R. [UNESP]-
Autor(es): dc.creatorSchavinski, Aline Z.-
Autor(es): dc.creatorDeluque, Amanda L.-
Autor(es): dc.creatorVolpato, Gustavo T.-
Autor(es): dc.creatorCampos, Kleber E.-
Data de aceite: dc.date.accessioned2022-02-22T00:10:54Z-
Data de disponibilização: dc.date.available2022-02-22T00:10:54Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2174/1871530319bb6191204130007-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196952-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196952-
Descrição: dc.descriptionBackground: Limited studies have been canied out with prednisone (PRED) in treatment by glucose intolerant individuals, even in this model the animals presented low blood glucose levels at adulthood, by the high regenerative capacity of beta-cell. Objective: The aim was to evaluate the effects of the treatment of PRED in mild diabetes on biochemical and immunological biomarkers. Methods: Rats were randomly divided into four groups: control (C), treated control C+PRED (treatment of 1.25 mg/Kg/day PRED); diabetic DM (mild diabetes) and treated diabetic DM PRED (treatment with same dose as C+PRED group). Untreated groups received vehicle, adjusted volume to body weight. The treatment lasted 21 days and measured body weight, food and water intake, and glycemia weekly. In the 3rd week, the Oral Glucose Tolerance Test (OGTT) and the Insulin Tolerance Test (ITT) was performed. On the last day, the rats were killed and the blood was collected for biochemical analyzes, leukogram and imm.unoglobulin G levels. Results: There was a significant decrease in body weight in mild diabetes; however, the treatment in diabetic groups increased food intake, glycemia, and the number of total leukocytes, lymphocytes and neutrophils. On the other hand, it decreased the levels of triglycerides, high -density and very low density lipoproteins. In addition, diabetic groups showed glucose intolerance and mild insulin resistance, confirming that this model induces glucose intolerant in adult life. Conclusion: The results showed that the use of prednisone is not recommended for glucose intolerant individuals and should he replaced in order to not to aggravate this condition.-
Descrição: dc.descriptionFundacao de Amparo a Pesquisa do Estado de Mato Grosso (FAPEMAT), Cuiaba, Brazil (2014-2016)-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Inst Biosci, Postgrad Program Pharmacol & Biotechnol, Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Physiol, Sao Paulo, Brazil-
Descrição: dc.descriptionFed Univ Mato Grosso UFMT, Inst Biol Sci & Hlth, Lab Syst Physiol & Reprod Toxicol, Barra Do Garcas, Mato Grosso, Brazil-
Descrição: dc.descriptionSao Paulo State Univ UNESP, Inst Biosci, Postgrad Program Pharmacol & Biotechnol, Botucatu, SP, Brazil-
Descrição: dc.descriptionFundacao de Amparo a Pesquisa do Estado de Mato Grosso (FAPEMAT), Cuiaba, Brazil (2014-2016): 002 - 004/2015-
Descrição: dc.descriptionFundacao de Amparo a Pesquisa do Estado de Mato Grosso (FAPEMAT), Cuiaba, Brazil (2014-2016): 36016.541.21414.17082016-
Formato: dc.format797-805-
Idioma: dc.languageen-
Publicador: dc.publisherBentham Science Publ Ltd-
Relação: dc.relationEndocrine Metabolic & Immune Disorders-drug Targets-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectDiabetes-
Palavras-chave: dc.subjectglucocorticoids-
Palavras-chave: dc.subjectglycometabolism-
Palavras-chave: dc.subjectimmunosuppressant-
Palavras-chave: dc.subjectlipometabolism-
Palavras-chave: dc.subjectprednisone-
Título: dc.titleThe Treatment of Prednisone in Mild Diabetic Rats: Biochemical Parameters and Cell Response-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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