Protective effects of desipramine on alveolar bone in experimental periodontitis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniv Fed Maranhao-
Autor(es): dc.contributorUniversidade Estadual de Ponta Grossa (UEPG)-
Autor(es): dc.contributorFac Sci Tocantins-
Autor(es): dc.contributorUniv Ceuma-
Autor(es): dc.contributorUniv Taubate-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorNova Southeastern Univ-
Autor(es): dc.contributorUniv Fed Alfenas-
Autor(es): dc.creatorBranco-de-Almeida, Luciana S.-
Autor(es): dc.creatorFranco, Gilson C. N.-
Autor(es): dc.creatorCastro, Myrella L.-
Autor(es): dc.creatorVieira, Mayana S.-
Autor(es): dc.creatorGalvao-Moreira, Leonardo-
Autor(es): dc.creatorCortelli, Sheila C.-
Autor(es): dc.creatorAnbinder, Ana L. [UNESP]-
Autor(es): dc.creatorKawai, Toshihisa-
Autor(es): dc.creatorRosalen, Pedro L.-
Data de aceite: dc.date.accessioned2022-02-22T00:10:53Z-
Data de disponibilização: dc.date.available2022-02-22T00:10:53Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-06-05-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/JPER.19-0569-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196943-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196943-
Descrição: dc.descriptionBackground Desipramine is a tricyclic antidepressant with immune-modulatory activity, whose effects on ligature-induced periodontitis are yet to be investigated. Hence, its actions on alveolar bone resorption, gingival collagen content and key inflammatory mediators were herewith analyzed. Methods A total of 60 male Wistar rats were randomly assigned into three groups: 1) control: rats without ligature treated with vehicle (saline); 2) ligature: rats with ligature-induced periodontitis treated with vehicle; 3) ligature + desipramine: rats with ligature-induced periodontitis treated with desipramine (20 mg/kg/d in vehicle). Mandibles and gingival tissues were collected 3 or 15 days after ligature insertion (or no ligature insertion for controls) and treatments. Alveolar bone resorption and gingival collagen fibers were histologically analyzed using either HE or picrosirius red staining. Gingival mRNA expressions of interleukin (IL)-1 beta, inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, matrix metalloproteinase (MMP)-9 and tissue inhibitor of metalloproteinase (TIMP)-1 were obtained through reverse transcription polymerase chain reaction. MMP-9 activity was analyzed by zymography. Results Alveolar bone loss was significantly reduced in the ligature + desipramine group (P < 0.05), whereas gingival collagen degradation was like the ligature group (P > 0.05). Desipramine administration downregulated mRNA expressions of IL-1 beta, iNOS, COX-2, and TIMP-1 when compared to vehicle alone in the ligature group (P < 0.05). MMP-9 expression and MMP-9/TIMP-1 ratio were similar among rats with ligature-induced periodontitis (P > 0.05); however, MMP-9 activity was lower in the group treated with desipramine (P < 0.05). Conclusion Desipramine administration reduced alveolar bone loss as histologically observed, and modulated key bone remodeling and inflammatory mediators in rats with ligature-induced periodontitis.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionNational Institutes of Health/National Institute of Dental and Craniofacial Research (NIH/NIDCR, USA)-
Descrição: dc.descriptionMaranhao State Research Foundation (FAPEMA, Brazil)-
Descrição: dc.descriptionUniv Fed Maranhao, Post Grad Program Dent, Sao Luis, Maranhao, Brazil-
Descrição: dc.descriptionUniv Estadual Ponta Grossa, Dept Gen Biol, Ponta Grossa, Parana, Brazil-
Descrição: dc.descriptionFac Sci Tocantins, Araguaina, Tocantins, Brazil-
Descrição: dc.descriptionUniv Ceuma, Post Grad Program Dent, Sao Luis, Maranhao, Brazil-
Descrição: dc.descriptionUniv Fed Maranhao, Sch Med, Sao Luis, Maranhao, Brazil-
Descrição: dc.descriptionUniv Taubate, Nucleus Periodontal Res, Taubate, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dept Biosci & Oral Diag, Sao Jose Dos Campos, SP, Brazil-
Descrição: dc.descriptionNova Southeastern Univ, Coll Dent Med, Ft Lauderdale, FL 33314 USA-
Descrição: dc.descriptionUniv Fed Alfenas, Biol Sci Grad Program, Rua Gabriel Monteiroda Silva 700,Predio E Sala, BR-37130001 Alfenas, MG, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dept Biosci & Oral Diag, Sao Jose Dos Campos, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2008/00566-6-
Descrição: dc.descriptionCAPES: 4073/08-8-
Descrição: dc.descriptionNational Institutes of Health/National Institute of Dental and Craniofacial Research (NIH/NIDCR, USA): R15 DE027851-
Descrição: dc.descriptionMaranhao State Research Foundation (FAPEMA, Brazil): 1818/2012-
Formato: dc.format10-
Idioma: dc.languageen-
Publicador: dc.publisherWiley-Blackwell-
Relação: dc.relationJournal Of Periodontology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectbone resorption-
Palavras-chave: dc.subjectcollagen-
Palavras-chave: dc.subjectdesipramine-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectperiodontal diseases-
Título: dc.titleProtective effects of desipramine on alveolar bone in experimental periodontitis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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