Preparation and physicochemical characterization of drug loaded in castor oil-based polyurethane

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal do ABC (UFABC)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorFortes, Amanda C.-
Autor(es): dc.creatorBezzon, Vinicius D. N.-
Autor(es): dc.creatorAraujo, Gabriel L. B. de-
Autor(es): dc.creatorSantos, Carlos O. P. [UNESP]-
Autor(es): dc.creatorFerraz, Humberto G.-
Data de aceite: dc.date.accessioned2022-02-22T00:10:44Z-
Data de disponibilização: dc.date.available2022-02-22T00:10:44Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10973-019-08607-9-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196893-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196893-
Descrição: dc.descriptionCastor oil is an environmentally friendly alternative to hydrocarbon-based feedstocks for the synthesis of polyurethanes due to its major constituent, ricinoleic acid. This work aimed to obtain and characterize castor oil-based polyurethane (coPU) systems containing domperidone and verapamil hydrochloride, separately, as model drugs. The drug-loaded coPU systems were obtained by solvent evaporation method and were characterized by differential scanning calorimetry, thermogravimetry, Fourier transform infrared spectroscopy and X-ray powder diffraction. Additionally, dissolution studies and scanning electron microscopy were performed. Verapamil hydrochloride was successfully incorporated in coPU, once it interacted through hydrogen bonds, and this system showed as a potential candidate for sustained drug release. Domperidone precipitated during solvent evaporation, resulting in a drug suspension into the polymer matrix. However, around 20% of domperidone interacted chemically with the polymer by the reaction of the active hydrogen of domperidone imidazole groups with the terminal isocyanate of the prepolymer. Finally, the drug release profile is guided by the drug-polymer physicochemical interaction, which will depend on the drug and polymer functional groups that are stereochemically available.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniv Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, BR-05508000 Sao Paulo, Brazil-
Descrição: dc.descriptionFed Univ ABC UFABC, Ctr Nat & Human Sci CCNH, BR-09210580 Santo Andre, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Chem Inst, Dept Phys Chem, BR-14800060 Araraquara, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Chem Inst, Dept Phys Chem, BR-14800060 Araraquara, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2013/14744-1-
Formato: dc.format1949-1957-
Idioma: dc.languageen-
Publicador: dc.publisherSpringer-
Relação: dc.relationJournal Of Thermal Analysis And Calorimetry-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectCastor oil-based polyurethane-
Palavras-chave: dc.subjectPolymer matrix-
Palavras-chave: dc.subjectDrug release-
Palavras-chave: dc.subjectDissolution-
Palavras-chave: dc.subjectSustained release-
Título: dc.titlePreparation and physicochemical characterization of drug loaded in castor oil-based polyurethane-
Tipo de arquivo: dc.typelivro digital-
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