Teriparatide improves microarchitectural characteristics of peri-implant bone in orchiectomized rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorMcMaster Univ-
Autor(es): dc.contributorRes Prod Scholarship Proc 306389 2017 7-
Autor(es): dc.creatorGomes-Ferreira, P. H. S. [UNESP]-
Autor(es): dc.creatorOliveira, D. de [UNESP]-
Autor(es): dc.creatorFrigerio, P. B. [UNESP]-
Autor(es): dc.creatorSouza Batista, F. R. de [UNESP]-
Autor(es): dc.creatorGrandfield, K.-
Autor(es): dc.creatorOkamoto, R. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:10:39Z-
Data de disponibilização: dc.date.available2022-02-22T00:10:39Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-05-07-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00198-020-05431-y-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196860-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196860-
Descrição: dc.descriptionThis study evaluated the peri-implant bone repair in orchiectomized rats receiving intermittently PTH 1-34. The treatment returned the bone quality and quantity of the animals to normal in the computerized microtomography, laser confocal microscopy, and histological analysis. The PTH 1-34 promoted marked bone formation with increased volume, improved quality, and greater bone turnover. Introduction Osteoporosis can be a problem in implant osseointegration. So this study aimed to evaluate the quantity and quality of peri-implant bone repair in orchiectomized Wistar rats receiving intermittently administered PTH 1-34. Methods Animals (n = 24) were divided into 3 groups: healthy control (SHAM), orchiectomized (ORQ), and orchiectomized and treated with 0.5 mu g/kg/day PTH 1-34 (TERI), and each received an implant in the right and left tibial metaphysis, which was allowed to repair for 60 days. The resultant bone formation was evaluated through computerized microtomography (micro-CT) to compare the percent bone volume (BV/TV), trabecular thickness (Tb.Th), trabecular number and separation (Tb.N, Tb.Sp), and bone implant contact (BIC) through the intersection surface (i.S) between groups. Laser confocal microscopy was used to evaluate fluorochrome areas for mineral apposition rate (MAR) and neoformed bone area (NBA). In addition, histological evaluation of calcified tissues with Stevenel blue and alizarin red staining was performed. Results Treatment with PTH 1-34 returned the bone quality and quantity of the osteoporotic animal to normal, as the TERI group presented statistically significant higher values for BV/TV, Tb.Th, and BIC parameters compared with ORQ (p < 0.05), but when compared with SHAM (p > 0.05), no statistical difference was noted. In addition, in the bone turnover analysis (MAR, NBA) for TERI, the highest results are presented, followed by SHAM, and then ORQ (TERI x ORQ: p < 0.05). Conclusions Intermittent treatment with PTH 1-34 on orchiectomized animals promoted marked bone formation with increased volume, improved quality, and greater bone turnover in the peri-implant space, returning the bone quality and quantity to the present standard in healthy animals.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSao Paulo State Univ, Aracatuba Dent Sch, Dept Surg, Rua Jose Bonifacio 1193, BR-16015050 Aracatuba, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Aracatuba Dent Sch, Integrated Clin, Rua Jose Bonifacio 1193, BR-16015050 Aracatuba, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Aracatuba Dent Sch, Dept Basic Sci, Aracatuba, SP, Brazil-
Descrição: dc.descriptionMcMaster Univ, Dept Mat Sci & Engn, Hamilton, ON, Canada-
Descrição: dc.descriptionRes Prod Scholarship Proc 306389 2017 7, Aracatuba, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Aracatuba Dent Sch, Dept Surg, Rua Jose Bonifacio 1193, BR-16015050 Aracatuba, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Aracatuba Dent Sch, Integrated Clin, Rua Jose Bonifacio 1193, BR-16015050 Aracatuba, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Aracatuba Dent Sch, Dept Basic Sci, Aracatuba, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2015/04649-7-
Descrição: dc.descriptionFAPESP: 2015/14688-0-
Formato: dc.format1807-1815-
Idioma: dc.languageen-
Publicador: dc.publisherSpringer-
Relação: dc.relationOsteoporosis International-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectBone histomorphometry-
Palavras-chave: dc.subjectBone QCT-
Palavras-chave: dc.subjectImplants-
Palavras-chave: dc.subjectMicro-computed tomography-
Palavras-chave: dc.subjectOsseointegration-
Palavras-chave: dc.subjectOsteoporosis-
Palavras-chave: dc.subjectPTH-
Título: dc.titleTeriparatide improves microarchitectural characteristics of peri-implant bone in orchiectomized rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.