Influence of apitoxin and melittin from Apis mellifera bee on Staphylococcus aureus strains

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorMarques Pereira, Ana Flavia [UNESP]-
Autor(es): dc.creatorAlbano, Mariana [UNESP]-
Autor(es): dc.creatorBergamo Alves, Fernanda Cristina [UNESP]-
Autor(es): dc.creatorMurbach Teles Andrade, Bruna Fernanda [UNESP]-
Autor(es): dc.creatorFurlanetto, Alessandra [UNESP]-
Autor(es): dc.creatorMores Rall, Vera Lucia [UNESP]-
Autor(es): dc.creatorSantos, Lucilene Delazari dos [UNESP]-
Autor(es): dc.creatorOrsi, Ricardo de Oliveira [UNESP]-
Autor(es): dc.creatorFernandes Junior, Ary [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:10:33Z-
Data de disponibilização: dc.date.available2022-02-22T00:10:33Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.micpath.2020.104011-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196829-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196829-
Descrição: dc.descriptionThe antibacterial activities of apitoxin, a venom produced by Apis mellifera bee, and melittin, an antimicrobial peptide from apitoxin, were tested against planktonic and biofilm states of Staphylococcus aureus methicillin-resistant (MRSA), including clinical, and enterotoxin-producing isolates. Also, the synergism of apitoxin and melittin in combination with oxacillin were evaluated as well. The induced morphological changes on S. aureus cells of both products were detected by transmission electronic microscopy (TEM). The minimum inhibitory concentration (MIC) values were 7.2 mu g/mL, and 6.7 mu g/mL, for apitoxin and melittin, respectively. The minimum bactericidal concentration (MBC) values were 28.7 mu g/mL, and 26 mu g/mL for apitoxin and melittin, respectively. The time-kill curve assays of apitoxin or melittin with oxacillin exhibited bactericidal synergism against MRSA isolates. TEM images showed cell distortion, cell disintegration with leakage of cytoplasmic content and loss of cytoplasm content. However, apitoxin and melittin did not interfere with staphylococcal enterotoxin production or release. Thus, apitoxin and melittin are potential agents against MRSA that can serve as possible models for new antibacterial drugs.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionElectronic Microscopy Center, Institute of Biosciences of Botucatu (IBB), Sao Paulo State University (UNESP), Botucatu, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dept Microbiol & Immunol, BR-18618691 Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, CEVAP Ctr Study Venoms & Venomous Anim, BR-18610307 Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dept Microbiol & Immunol, BR-18618691 Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, CEVAP Ctr Study Venoms & Venomous Anim, BR-18610307 Botucatu, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2015/14278-6-
Descrição: dc.descriptionCNPq: 162208/2015-4-
Formato: dc.format8-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationMicrobial Pathogenesis-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectantibacterial activity-
Palavras-chave: dc.subjectBee venom-
Palavras-chave: dc.subjectAntimicrobial peptides-
Palavras-chave: dc.subjectMethicillin-resistant Staphylococcus aureus-
Palavras-chave: dc.subjectMRSA-
Palavras-chave: dc.subjectEnterotoxin-producing S. aureus-
Título: dc.titleInfluence of apitoxin and melittin from Apis mellifera bee on Staphylococcus aureus strains-
Tipo de arquivo: dc.typelivro digital-
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