Emerging role of PTEN loss in evasion of the immune response to tumours

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorQueens Univ-
Autor(es): dc.contributorClin Hosp Ribeirao Preto-
Autor(es): dc.creatorVidotto, Thiago-
Autor(es): dc.creatorMelo, Camila Morais-
Autor(es): dc.creatorCastelli, Erick [UNESP]-
Autor(es): dc.creatorKoti, Madhuri-
Autor(es): dc.creatorReis, Rodolfo Borges dos-
Autor(es): dc.creatorSquire, Jeremy A.-
Data de aceite: dc.date.accessioned2022-02-22T00:10:32Z-
Data de disponibilização: dc.date.available2022-02-22T00:10:32Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-04-24-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41416-020-0834-6-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196822-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196822-
Descrição: dc.descriptionMutations in PTEN activate the phosphoinositide 3-kinase (PI3K) signalling network, leading to many of the characteristic phenotypic changes of cancer. However, the primary effects of this gene on oncogenesis through control of the PI3K-AKT-mammalian target of rapamycin (mTOR) pathway might not be the only avenue by which PTEN affects tumour progression. PTEN has been shown to regulate the antiviral interferon network and thus alter how cancer cells communicate with and are targeted by immune cells. An active, T cell-infiltrated microenvironment is critical for immunotherapy success, which is also influenced by mutations in DNA damage repair pathways and the overall mutational burden of the tumour. As PTEN has a role in the maintenance of genomic integrity, it is likely that a loss of PTEN affects the immune response at two different levels and might therefore be instrumental in mediating failed responses to immunotherapy. In this review, we summarise findings that demonstrate how the loss of PTEN function elicits specific changes in the immune response in several types of cancer. We also discuss ongoing clinical trials that illustrate the potential utility of PTEN as a predictive biomarker for immune checkpoint blockade therapies.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionUniv Sao Paulo, Med Sch Ribeirao Preto, Dept Genet, Ribeirao Preto, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Med Sch Botucatu, Dept Pathol, Botucatu, SP, Brazil-
Descrição: dc.descriptionQueens Univ, Queens Canc Res Inst, Canc Biol & Genet, Kingston, ON, Canada-
Descrição: dc.descriptionQueens Univ, Dept Biomed & Mol Sci, Kingston, ON, Canada-
Descrição: dc.descriptionClin Hosp Ribeirao Preto, Ribeirao Preto, Brazil-
Descrição: dc.descriptionQueens Univ, Dept Pathol & Mol Med, Kingston, ON, Canada-
Descrição: dc.descriptionUniv Estadual Paulista, Med Sch Botucatu, Dept Pathol, Botucatu, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2015/22785-5-
Descrição: dc.descriptionFAPESP: 2017/08614-9-
Descrição: dc.descriptionFAPESP: 2015/09111-5-
Descrição: dc.descriptionCNPq: 306864/2014-2-
Formato: dc.format1732-1743-
Idioma: dc.languageen-
Publicador: dc.publisherNature Publishing Group-
Relação: dc.relationBritish Journal Of Cancer-
???dc.source???: dc.sourceWeb of Science-
Título: dc.titleEmerging role of PTEN loss in evasion of the immune response to tumours-
Aparece nas coleções:Repositório Institucional - Unesp

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