Injectable MMP-Responsive Nanotube-Modified Gelatin Hydrogel for Dental Infection Ablation

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniv Michigan-
Autor(es): dc.contributorUniv Fed Pelotas-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorRibeiro, Juliana S.-
Autor(es): dc.creatorBordini, Ester A. F. [UNESP]-
Autor(es): dc.creatorFerreira, Jessica A.-
Autor(es): dc.creatorMei, Ling-
Autor(es): dc.creatorDubey, Nileshkumar-
Autor(es): dc.creatorFenno, J. Christopher-
Autor(es): dc.creatorPiva, Evandro-
Autor(es): dc.creatorLund, Rafael G.-
Autor(es): dc.creatorSchwendeman, Anna-
Autor(es): dc.creatorBottino, Marco C.-
Data de aceite: dc.date.accessioned2022-02-22T00:10:26Z-
Data de disponibilização: dc.date.available2022-02-22T00:10:26Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-04-08-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acsami.9b22964-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196785-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196785-
Descrição: dc.descriptionA photocrosslinkable gelatin methacryloyl (GelMA) hydrogel has been widely examined in regenerative engineering because of its good cell-tissue affinity and degradability in the presence of matrix metalloproteinases. A halloysite aluminosilicate nanotube (HNT) is a known reservoir for the loading and sustained delivery of therapeutics. Here, we formulate injectable chlorhexidine (CHX)-loaded nanotube-modified GelMA hydrogel that is cytocompatible and biodegradable and provides sustained release of CHX for infection ablation while displaying good biocompatibility. The effects of HNTs and CHX on hydrogel degradability and mechanical properties, as well as on the kinetics of CHX release, and on the antimicrobial efficacy against oral pathogens were systematically assessed. Cytocompatibility in stem cells from human exfoliated deciduous teeth and inflammatory response in vivo using a subcutaneous rat model were determined. Our hydrogel system, that is, (CHX)-loaded nanotube-modified GelMA showed minimum localized inflammatory responses, supporting its ability for drug delivery applications. Moreover, we showed that the incorporation of CHX-loaded nanotubes reduces the mechanical properties, increases the swelling ratio, and diminishes the degradation rate of the hydrogels. Importantly, the presence of CHX-loaded nanotubes inhibits bacterial growth with minimal cell toxicity. Our findings provide a new strategy to modify GelMA hydrogel with chlorhexidine-loaded nanotubes for clinical use as an injectable drug delivery strategy for dental infection ablation.-
Descrição: dc.descriptionNational Institutes of Health (NIH, National Institute of Dental and Craniofacial Research/NIDCR)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionUniv Michigan, Sch Dent, Dept Cariol Restorat Sci & Endodont, Ann Arbor, MI 48109 USA-
Descrição: dc.descriptionUniv Fed Pelotas, Sch Dent, Dept Restorat Dent, BR-96010610 Pelotas, RS, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Sch Dent, Dept Dent Mat & Prosthodont, BR-01049010 Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Michigan, Coll Pharm, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA-
Descrição: dc.descriptionUniv Michigan, Biointerfaces Inst, Ann Arbor, MI 48109 USA-
Descrição: dc.descriptionUniv Michigan, Sch Dent, Dept Biol & Mat Sci & Prosthodont, Ann Arbor, MI 48109 USA-
Descrição: dc.descriptionSao Paulo State Univ, Sch Dent, Dept Dent Mat & Prosthodont, BR-01049010 Araraquara, SP, Brazil-
Descrição: dc.descriptionNational Institutes of Health (NIH, National Institute of Dental and Craniofacial Research/NIDCR): K08DE023552-
Descrição: dc.descriptionNational Institutes of Health (NIH, National Institute of Dental and Craniofacial Research/NIDCR): R01DE026578-
Formato: dc.format16006-16017-
Idioma: dc.languageen-
Publicador: dc.publisherAmer Chemical Soc-
Relação: dc.relationAcs Applied Materials & Interfaces-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectdrug delivery-
Palavras-chave: dc.subjecthydrogel-
Palavras-chave: dc.subjectinfection-
Palavras-chave: dc.subjectendodontics-
Palavras-chave: dc.subjectdentistry-
Palavras-chave: dc.subjectmatrix metalloproteinases-
Título: dc.titleInjectable MMP-Responsive Nanotube-Modified Gelatin Hydrogel for Dental Infection Ablation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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