Treatment of experimental periodontitis with chlorhexidine as adjuvant to scaling and root planing

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniv Fed Pelotas-
Autor(es): dc.contributorUniv Western Sao Paulo-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorAarhus Univ-
Autor(es): dc.creatorPrietto, Nubia Rosa-
Autor(es): dc.creatorMartins, Thiago Marchi-
Autor(es): dc.creatorSantinoni, Carolina dos Santos-
Autor(es): dc.creatorPola, Natalia Marcumini-
Autor(es): dc.creatorErvolino, Edilson [UNESP]-
Autor(es): dc.creatorBielemann, Amalia Machado-
Autor(es): dc.creatorManzolli Leite, Fabio Renato-
Data de aceite: dc.date.accessioned2022-02-22T00:10:22Z-
Data de disponibilização: dc.date.available2022-02-22T00:10:22Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2019.104600-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196754-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196754-
Descrição: dc.descriptionObjectives: To assess whether subgingival irrigation with 0.12 % or 0.2 % chlorhexidine (CHX) immediately after scaling and root planing (SRP) enhances periodontal tissue repair compared to irrigation with saline solution (control). Materials and methods: Periodontitis was ligature-induced in rat molars for 7 days. Animals were distributed into three groups: 1) SRP group, SRP and irrigation with 0.9 % saline (n = 30); 2) SRP + 0.12 % CHX group, SRP and irrigation with 0.12 % CHX (n = 30); 3) SRP + 0.2 % CHX group, SRP and irrigation with 0.2 % CHX (n = 30). Animals were killed at 7, 15, and 30 days after treatment. Furcation region was histometrically analyzed to determine the bone area. Immunohistochemical reactions were performed for receptor activator of nuclear factor-kB ligand (RANKL), osteoprotegerin (OPG) and tartrate-resistant acid phosphatase (TRAP). Results: Both chlorhexidine groups presented less inflammation and improved tissue repair along the entire experiment when compared with the SRP group. In the histometric analysis at 7, 15 and 30 days, SRP group (4.58 +/- 2.51 mm2, 4.21 +/- 1.25 mm2, 3.49 +/- 1.48 mm2), showed statistically less bone area than groups SRP + 0.12 % CHX (1.86 +/- 1.11 mm(2) ; 0.79 +/- 0.27 mm(2) ; 0.34 +/- 0.14 mm(2)) and SRP + 0.2 % CHX (1.14 +/- 0.51 mm(2); 0.98 +/- 0.40 mm(2) ; 0.41 +/- 0.21 mm(2)). Both chlorhexidine concentrations modulated the expression of TRAP, RANKL and OPG. Conclusions: Subgingival irrigation with chlorhexidine contributed for a quicker shift from a proinflammatory destructive profile to healing of periodontal tissues.-
Descrição: dc.descriptionFAPERGS (the Research Support Foundation of Rio Grande do Sul)-
Descrição: dc.descriptionUniv Fed Pelotas, Sch Dent, Grad Program Dent, Pelotas, RS, Brazil-
Descrição: dc.descriptionUniv Western Sao Paulo, Dent Sch Presidente Prudente, Grad Program Dent GPD Masters Degree, Presidente Prudente, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dent Sch Aracatuba, Dept Basic Sci, Sao Paulo, Brazil-
Descrição: dc.descriptionAarhus Univ, Dept Dent & Oral Hlth, Sect Periodontol, Aarhus, Denmark-
Descrição: dc.descriptionSao Paulo State Univ, Dent Sch Aracatuba, Dept Basic Sci, Sao Paulo, Brazil-
Formato: dc.format6-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationArchives Of Oral Biology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectPeriodontitis-
Palavras-chave: dc.subjectPeriodontal diseases-
Palavras-chave: dc.subjectRats-
Palavras-chave: dc.subjectWound healing-
Palavras-chave: dc.subjectDental scaling-
Palavras-chave: dc.subjectChlorhexidine-
Título: dc.titleTreatment of experimental periodontitis with chlorhexidine as adjuvant to scaling and root planing-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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