Antidiabetic activity of Musa x paradisiaca extracts in streptozotocin-induced diabetic rats and chemical characterization by HPLC-DAD-MS

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Autor(es): dc.contributorUniv Fed Parana-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.creatorVilhena, R. O.-
Autor(es): dc.creatorFigueiredo, I. D. [UNESP]-
Autor(es): dc.creatorBaviera, A. M. [UNESP]-
Autor(es): dc.creatorSilva, D. B.-
Autor(es): dc.creatorMarson, B. M.-
Autor(es): dc.creatorOliveira, J. A. [UNESP]-
Autor(es): dc.creatorPeccinini, R. G. [UNESP]-
Autor(es): dc.creatorBorges, I. K.-
Autor(es): dc.creatorPontarolo, R.-
Data de aceite: dc.date.accessioned2022-02-22T00:10:22Z-
Data de disponibilização: dc.date.available2022-02-22T00:10:22Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-05-23-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jep.2020.112666-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196752-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196752-
Descrição: dc.descriptionEthnopharmacological relevance: The Musa x paradisiaca L. inflorescence, known as banana blossom or banana heart, is used in traditional medicine for the treatment of diabetes mellitus. Aim of the study: The aim of the study was to investigate the antidiabetic activity of aqueous extracts and fractions prepared from the bracts and flowers of Musa x paradisiaca in streptozotocin (STZ)-induced diabetic rats and to chemically characterize the extracts. Materials and methods: Standard aqueous extracts of the flowers, bracts, and their fractions were prepared and their chemical composition was determined tentatively by high-performance liquid chromatography coupled to diode-array detection and mass spectrometry (HPLC-DAD-MS). Changes in fasting glycemia and oral glucose tolerance were evaluated in STZ-induced diabetic rats (n = 8) treated with aqueous extracts of Musa x paradisiaca (200 mg/kg) for 20 days. Results: Chemical analyses detected 21 compounds and 17 metabolites were identified, among which were glycosylated and acetylated phenylpropanoids of p-coumaric acid and caffeic acid, as well as a glycosylated flavonol and anthocyanins. Following 15 days of treatment, the bract aqueous extracts and the methanolic fraction of the flower had significant effects on the glycemic profile after glucose load in diabetic rats as compared with the untreated diabetic group. Conclusions: The results of the present study show the antidiabetic potential of extracts of the flowers and bracts of M. x paradisiaca.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFUNDECT (Fundacao de Apoio ao Desenvolvimento do Ensino, Ciencia e Tecnologia do estado de Mato Grosso do Sul)-
Descrição: dc.descriptionUniv Fed Parana, Dept Farm, 632 Lothario Meissner Ave, BR-80210170 Curitiba, Parana, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Anal Clin, Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Fed Mato Grosso do Sul, Fac Ciencias Farmaceut Alimentos & Nutr, Lab Prod Nat & Espectrometria Massas, Campo Grande, MS, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Principios At Nat & Toxicol, Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Londrina, Dept Ciencias Patol, Londrina, Parana, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Anal Clin, Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Principios At Nat & Toxicol, Araraquara, SP, Brazil-
Formato: dc.format6-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationJournal Of Ethnopharmacology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectBanana-
Palavras-chave: dc.subjectHydroxycinnamic acid derivatives-
Palavras-chave: dc.subjectHPLC-DAD-MS-
Palavras-chave: dc.subjectAnthocyanins-
Palavras-chave: dc.subjectDiabetes mellitus-
Título: dc.titleAntidiabetic activity of Musa x paradisiaca extracts in streptozotocin-induced diabetic rats and chemical characterization by HPLC-DAD-MS-
Tipo de arquivo: dc.typelivro digital-
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