Effect of terlipressin on renal function in cirrhotic patients with acute upper gastrointestinal bleeding

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorGen Hosp Northern Theater Command-
Autor(es): dc.contributorShenyang Pharmaceut Univ-
Autor(es): dc.contributorSixth Hosp Shenyang-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorSan Camillo Hosp-
Autor(es): dc.contributorJinzhou Med Univ-
Autor(es): dc.contributorDalian Med Univ-
Autor(es): dc.creatorZhang, Jingqiao-
Autor(es): dc.creatorLiu, Jie-
Autor(es): dc.creatorWu, Yunhai-
Autor(es): dc.creatorRomeiro, Fernando Gomes [UNESP]-
Autor(es): dc.creatorSandri, Giovanni Battista Levi-
Autor(es): dc.creatorZhou, Xinmiao-
Autor(es): dc.creatorLi, Miaomiao-
Autor(es): dc.creatorQi, Xingshun-
Data de aceite: dc.date.accessioned2022-02-22T00:10:20Z-
Data de disponibilização: dc.date.available2022-02-22T00:10:20Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.21037/atm.2020.02.135-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196741-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196741-
Descrição: dc.descriptionBackground: Renal dysfunction is a serious morbidity in cirrhotic patients with acute upper gastrointestinal bleeding (AUGIB). Terlipressin is the first-line treatment choice for acute variceal bleeding and hepatorenal syndrome (HRS). This study aimed to assess the effect of terlipressin on renal function in patients with liver cirrhosis and AUGIB. Methods: We retrospectively reviewed 40 cirrhotic patients with AUGIB treated with terlipressin by an attending physician between January 2016 and June 2018. We analyzed the change of renal function parameters, including cystatin C (CysC) and creatinine (Cr), during the use of terlipressin and after terlipressin was stopped. We also identified the factors associated with renal function improvement in patients without active bleeding during the use of terlipressin. Results: During the use of terlipressin, CysC value was significantly reduced (1.3 +/- 0.8 vs. 1.1 +/- 0.7, P=0.001); Cr value was reduced, but the reduction was not statistically significant (68.8 +/- 24 vs. 65.5 +/- 23, P=0.817); the rate of CysC reduction was significantly higher in patients treated with terlipressin than those treated with somatostatin/octreotide (73.1% vs. 0%, P=0.005); the rate of Cr reduction was not significantly different between patients treated with terlipressin and somatostatin/octreotide (61.5% vs. 20%, P=0.148); no factor associated with CysC reduction was identified; higher hemoglobin, red blood cell, and platelet and lower prothrombin time and international normalized ratio at baseline were significantly associated with Cr reduction. After terlipressin was stopped, neither CysC nor Cr value was significantly reduced (P=0.852 and P=0.296). Conclusions: Terlipressin may be beneficial on preventing renal function impairment in cirrhotic patients with AUGIB.-
Descrição: dc.descriptionGen Hosp Northern Theater Command, Liver Cirrhosis Grp, Dept Gastroenterol, 83 Wenhua Rd, Shenyang 110840, Peoples R China-
Descrição: dc.descriptionShenyang Pharmaceut Univ, Postgrad Coll, Shenyang 110016, Peoples R China-
Descrição: dc.descriptionShenyang Pharmaceut Univ, Dept Pharmaceut Sci, Shenyang 110016, Peoples R China-
Descrição: dc.descriptionSixth Hosp Shenyang, ICU, Shenyang 110006, Peoples R China-
Descrição: dc.descriptionUniv Estadual Paulista UNESP, Dept Internal Med, Botucatu Med Sch, Botucatu, SP, Brazil-
Descrição: dc.descriptionSan Camillo Hosp, Div Gen Surg & Liver Transplantat, Rome, Italy-
Descrição: dc.descriptionJinzhou Med Univ, Postgrad Coll, Jinzhou 121001, Peoples R China-
Descrição: dc.descriptionDalian Med Univ, Postgrad Coll, Dalian 116044, Peoples R China-
Descrição: dc.descriptionUniv Estadual Paulista UNESP, Dept Internal Med, Botucatu Med Sch, Botucatu, SP, Brazil-
Formato: dc.format16-
Idioma: dc.languageen-
Publicador: dc.publisherAme Publ Co-
Relação: dc.relationAnnals Of Translational Medicine-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectTerlipressin-
Palavras-chave: dc.subjectcirrhosis-
Palavras-chave: dc.subjectbleeding-
Palavras-chave: dc.subjectacute kidney injury (AKI)-
Palavras-chave: dc.subjectcystatin C (CysC)-
Título: dc.titleEffect of terlipressin on renal function in cirrhotic patients with acute upper gastrointestinal bleeding-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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