Role of GnRH Isoforms in Paracrine/Autocrine Control of Zebrafish (Danio rerio) Spermatogenesis

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Autor(es): dc.contributorUniv Calgary-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorFallah, Hamideh P.-
Autor(es): dc.creatorRodrigues, Maira S. [UNESP]-
Autor(es): dc.creatorCorchuelo, Sheryll [UNESP]-
Autor(es): dc.creatorNobrega, Rafael H. [UNESP]-
Autor(es): dc.creatorHabibi, Hamid R.-
Data de aceite: dc.date.accessioned2022-02-22T00:10:04Z-
Data de disponibilização: dc.date.available2022-02-22T00:10:04Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1210/endocr/bqaa004-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196645-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196645-
Descrição: dc.descriptionIt is well established that hypothalamic GnRH (gonadotropin-releasing hormone) is one of the key peptides involved in the neuroendocrine control of testicular development and spermatogenesis. However, the role of GnRH as a paracrine regulator of testicular function has not been fully investigated. The present study demonstrates the presence of GnRH and its receptors in the zebrafish (Danio rerio) testis, and provides information on direct action of native GnRH isoforms (GnRH2 and GnRH3) on different stages of spermatogenesis in this model. Both GnRH2 and GnRH3 stimulated basal spermatogenesis by increasing numbers of type A(und) spermatogonia, spermatozoa, and testosterone release, and in this study GnRH2 exerted higher relative activity than GnRH3. Next, we evaluated the effects of GnRH isoforms on human chorionic gonadotropin (hCG)- and follicle-stimulating hormone (Fsh)-induced spermatogenesis. The 2 GnRH isoforms were found to have different effects on Fsh- and hCG-induced response depending on the stage of spermatogenesis and concentration of the peptides. The results provide strong support for the hypothesis that locally produced GnRH2 and GnRH3 are important components of the complex multifactorial system that regulates testicular germinal cell development and function in adult zebrafish.-
Descrição: dc.descriptionNatural Sciences and Engineering Research Council (NSERC)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniv Calgary, Dept Biol Sci, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada-
Descrição: dc.descriptionSao Paulo State Univ, Dept Morphol, Reprod & Mol Biol Grp, Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dept Morphol, Reprod & Mol Biol Grp, Botucatu, SP, Brazil-
Descrição: dc.descriptionNatural Sciences and Engineering Research Council (NSERC): 1021837-
Descrição: dc.descriptionFAPESP: 17/15793-7-
Descrição: dc.descriptionFAPESP: 18/15319-6-
Formato: dc.format16-
Idioma: dc.languageen-
Publicador: dc.publisherEndocrine Soc-
Relação: dc.relationEndocrinology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectgonadotropin-releasing hormone (GnRH)-
Palavras-chave: dc.subjectchicken GnRH-II (GnRH2)-
Palavras-chave: dc.subjectsalmon GnRH (GnRH3)-
Palavras-chave: dc.subjecthuman chorionic gonadotropin (hCG)-
Palavras-chave: dc.subjectfollicle-stimulating hormone (Fsh)-
Palavras-chave: dc.subjectzebrafish spermatogenesis-
Título: dc.titleRole of GnRH Isoforms in Paracrine/Autocrine Control of Zebrafish (Danio rerio) Spermatogenesis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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