Hypotensive activity of Campomanesia xanthocarpa leaf extract: beyond angiotensin II type 1 receptor blockage

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorMelo Morais, Ingrid Beatriz de-
Autor(es): dc.creatorSilva, Denise Brentan-
Autor(es): dc.creatorCarollo, Carlos Alexandre-
Autor(es): dc.creatorFerreira-Neto, Marcos Luiz-
Autor(es): dc.creatorFidelis-de-Oliveira, Patricia [UNESP]-
Autor(es): dc.creatorBispo-da-Silva, Luiz Borges-
Data de aceite: dc.date.accessioned2022-02-22T00:09:58Z-
Data de disponibilização: dc.date.available2022-02-22T00:09:58Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-02-20-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/14786419.2020.1727467-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196623-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196623-
Descrição: dc.descriptionThe ability of Campomanesia xanthocarpa leaf extract (CXLE) to alter blood pressure and heart rate was evaluated in anesthetized rats. The CXLE-induced hypotension was evaluated before and after losartan, methylatropine, L-N(omega)-nitro-L-arginine methyl ester (L-NAME), hexamethonium, indomethacin, glibenclamide, or nifedipine administration. The constituents of CXLE were identified by LC-DAD-MS. CXLE decreased blood pressure in a dose-dependent manner; only the highest dose decreased heart rate. The hypotension induced by CXLE was sensitive only to losartan, nifedipine, and glibenclamide. L-NAME decreased the time to recover 50% of the hypotensive effect of CXLE without altering its magnitude. Flavan-3-ols, proanthocyanidins (dimers and trimers), and glycosylated flavonols were identified from CXLE. The chemical constituents of CXLE seem to induce not only angiotensin II type 1 receptor blockage, but also ATP-sensitive potassium channels activation and L-type voltage-dependent Ca2+ channels inactivation. Nitric oxide is involved in the maintenance of the hypotensive effect of CXLE.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundacao de Apoio ao Desenvolvimento do Ensino, Ciencia e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT)-
Descrição: dc.descriptionFed Univ Uberlandia UFU, Inst Biomed Sci, Dept Pharmacol, Campus Umuarama, Uberlandia, MG, Brazil-
Descrição: dc.descriptionFed Univ Mato Grosso UFMS, Lab Prod Nat & Espectrometria Massas LAPNEM, Campo Grande, MS, Brazil-
Descrição: dc.descriptionFed Univ Uberlandia UFU, Inst Biomed Sci, Dept Physiol, Campus Umuarama, Uberlandia, MG, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, UNESP, Inst Biosci, Dept Physiol, Botucatu, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, UNESP, Inst Biosci, Dept Physiol, Botucatu, SP, Brazil-
Descrição: dc.descriptionCNPq: IC-CNPQ2014-0352-
Formato: dc.format5-
Idioma: dc.languageen-
Publicador: dc.publisherTaylor & Francis Ltd-
Relação: dc.relationNatural Product Research-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectCardiovascular-
Palavras-chave: dc.subjectpotassium channels-
Palavras-chave: dc.subjectcalcium channels-
Palavras-chave: dc.subjectflavan-3-ols-
Palavras-chave: dc.subjectproanthocyanidins-
Palavras-chave: dc.subjectglycosylated flavonols-
Título: dc.titleHypotensive activity of Campomanesia xanthocarpa leaf extract: beyond angiotensin II type 1 receptor blockage-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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