Assessment of the hypoglycemic effect of Bixin in alloxan-induced diabetic rats: in vivo and in silico studies

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniv Fed Amapa-
Autor(es): dc.contributorUniv Sierra-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniv Nacl Autonoma Mexico-
Autor(es): dc.creatorKeita, Hady-
Autor(es): dc.creatorSantos, Cleydson Breno Rodrigues dos-
Autor(es): dc.creatorRamos, Matheus Merces-
Autor(es): dc.creatorPadilha, Elias Carvalho [UNESP]-
Autor(es): dc.creatorSerafim, Rodolfo Bortolozo-
Autor(es): dc.creatorCastro, Andres Navarrete-
Autor(es): dc.creatorAmado, Jesus Rafael Rodriguez-
Autor(es): dc.creatorSilva, Gabriel Monteiro da-
Autor(es): dc.creatorFerreira, Irlon Maciel-
Autor(es): dc.creatorGiuliatti, Silvana-
Autor(es): dc.creatorCarvalho, Jose Carlos Tavares-
Data de aceite: dc.date.accessioned2022-02-22T00:09:52Z-
Data de disponibilização: dc.date.available2022-02-22T00:09:52Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-02-11-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/07391102.2020.1724567-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196582-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196582-
Descrição: dc.descriptionThe objectives of this study were to extract and purify Bixin from the seeds of Bixa orellana and to evaluate its hypoglycemic activity in vivo, as well as, to conduct an in silico study of selectivity on peroxisome proliferator-activated receptors via molecular docking and molecular dynamics simulations. Oral administration of Bixin (10 mg/kg) significantly reduced their glucose level that was alloxan-induced diabetic rats. Bixin showed in silico selectivity on peroxisome proliferator-activated receptors (PPARs), particularly by the peroxisome proliferator-activated receptor gamma (PPAR gamma), which supports the hypoglycemic activity of Bixin. From the results obtained, it can be inferred that Bixin presents hypoglycemic characteristics, which was confirmed by the results obtained from the in vivo and in silico tests. Bixin may act by other pathways to control blood glucose and thus it is possible that it presents a different toxicity profile than troglitazone, rosiglitazone and pioglitazone. However, more studies on the activity and toxicity of Bixin are needed to evaluate for further clinical use.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionProcad Amazonia-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionUniv Fed Amapa, Dept Biol Sci & Hlth, Lab Drugs Discovery, Macapa, Brazil-
Descrição: dc.descriptionUniv Sierra, Div Postgrade, Ixtlan De Juarez, Mexico-
Descrição: dc.descriptionUniv Fed Amapa, Dept Biol Sci & Hlth, Lab Modeling & Computat Chem, Macapa, Brazil-
Descrição: dc.descriptionUniv Fed Amapa, Res Grp Biocatalysis & Apllied Organ Synth, Macapa, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dept Nat Act Principles & Toxicol, Fac Pharmaceut Sci, Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Dept Cellular & Mol Biol, Ribeirao Preto Med Sch, Ribeirao Preto, Brazil-
Descrição: dc.descriptionUniv Nacl Autonoma Mexico, Fac Chem, Dept Pharm, Lab Pharmacol Nat Prod, Mexico City, DF, Mexico-
Descrição: dc.descriptionUniv Sao Paulo, Ribeirao Preto Med Sch, Bioinformat Grp, Dept Genet, Ribeirao Preto, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dept Nat Act Principles & Toxicol, Fac Pharmaceut Sci, Araraquara, SP, Brazil-
Descrição: dc.descriptionCAPES: PNPD/20130076-14001012005P1-
Descrição: dc.descriptionProcad Amazonia: Auxpe - 1723/2018-
Descrição: dc.descriptionCNPq: 407768/2013-0-
Formato: dc.format12-
Idioma: dc.languageen-
Publicador: dc.publisherTaylor & Francis Inc-
Relação: dc.relationJournal Of Biomolecular Structure & Dynamics-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectBixin-
Palavras-chave: dc.subjecthypoglycemia-
Palavras-chave: dc.subjectPPAR gamma-
Palavras-chave: dc.subjectin vivo-
Palavras-chave: dc.subjectin silico-
Título: dc.titleAssessment of the hypoglycemic effect of Bixin in alloxan-induced diabetic rats: in vivo and in silico studies-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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