The Role of MicroRNAs in the Osseointegration Process

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniv Michigan-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorUniv Calif Los Angeles-
Autor(es): dc.contributorUniv Illinois-
Autor(es): dc.creatorSartori, Elisa Mattias [UNESP]-
Autor(es): dc.creatordas Neves, Andre Martins-
Autor(es): dc.creatorMagro-Filho, Osvaldo [UNESP]-
Autor(es): dc.creatorSilveira Mendonca, Daniela Baccelli-
Autor(es): dc.creatorKrebsbach, Paul H.-
Autor(es): dc.creatorCooper, Lyndon F.-
Autor(es): dc.creatorMendonca, Gustavo [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:09:33Z-
Data de disponibilização: dc.date.available2022-02-22T00:09:33Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2019-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.11607/jomi.6581-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196476-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196476-
Descrição: dc.descriptionRegulation of cellular function is key to bone formation at endosseous implant surfaces. Osseointegration was discovered prior to the discovery of genetic regulation of osteoinduction or characterization of mesenchymal stem cells. Understanding osseointegration in cellular and molecular terms has benefited from genome-wide characterization of this healing process at endosseous implants in vivo. These in vivo studies also demonstrate a role for osteoprogenitor cells and cells involved in immune regulation and osteoclastogenesis. The identification of noncoding RNAs, including microRNAs, as key factors controlling cell function has highlighted the role of microRNAs in cell differentiation control. This review summarizes emerging in vitro and in vivo investigations emphasizing the role of microRNAs in the osseointegration process. Many microRNAs influence key osteoinductive pathways controlling Osterix, runt-related transcription factor 2 (RUNX2), and bone morphogenetic protein (BMP)/SMAD function. Others influence the monocyte/macrophage lineage. While significant progress has been made in elucidating the mechanisms associated with the regulation of surface modulation of osteoblast differentiation by microRNAs, knowledge gaps are evident in the identification and characterization of microRNAs linked to osseointegration. Given existing knowledge regarding the varied expression of microRNAs and their role in inflammation, it is important to understand how microRNA expression may influence the process of bone accrual at implant surfaces during osseointegration.-
Descrição: dc.descriptionAcademy of Osseointegration/Osseointegration Foundation-
Descrição: dc.descriptionIADR - Implant Innovation Award-
Descrição: dc.descriptionUniv Michigan, Sch Dent, Dept Biol & Mat Sci, Ann Arbor, MI 48109 USA-
Descrição: dc.descriptionSao Paulo State Univ, Dept Oral Surg & Integrated Clin, Fac Dent, Aracatuba, Brazil-
Descrição: dc.descriptionUniv Fed Minas Gerais, Fac Dent, Belo Horizonte, MG, Brazil-
Descrição: dc.descriptionUniv Calif Los Angeles, Sch Dent, Los Angeles, CA 90024 USA-
Descrição: dc.descriptionUniv Illinois, Coll Dent, Chicago, IL USA-
Descrição: dc.descriptionSao Paulo State Univ, Dept Oral Surg & Integrated Clin, Fac Dent, Aracatuba, Brazil-
Formato: dc.format397-U357-
Idioma: dc.languageen-
Publicador: dc.publisherQuintessence Publishing Co Inc-
Relação: dc.relationInternational Journal Of Oral & Maxillofacial Implants-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectbone remodeling-
Palavras-chave: dc.subjectdental implants-
Palavras-chave: dc.subjectimplant surfaces-
Palavras-chave: dc.subjectmicroRNAs-
Palavras-chave: dc.subjectosseointegration-
Título: dc.titleThe Role of MicroRNAs in the Osseointegration Process-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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