Passiflora edulis Leaf Extract: Evidence of Antidiabetic and Antiplatelet Effects in Rats

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniv Fed Alfenas-
Autor(es): dc.contributorFed Univ Maranhdo-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorJose Rosario Vellano Univ-
Autor(es): dc.contributorSpanish Natl Canc Res Ctr CNIO-
Autor(es): dc.creatorCorrea Salles, Bruno Cesar-
Autor(es): dc.creatorSilva, Marcelo Aparecido da-
Autor(es): dc.creatorTaniguthi, Lara-
Autor(es): dc.creatorFerreira, Juliane Naiara-
Autor(es): dc.creatorRocha, Claudia Quintino da-
Autor(es): dc.creatorVilegas, Wagner [UNESP]-
Autor(es): dc.creatorDias, Pollyana Hammoud [UNESP]-
Autor(es): dc.creatorPennacchi, Paula Comune-
Autor(es): dc.creatorSilveira Duarte, Stella Maris da-
Autor(es): dc.creatorRodrigues, Maria Rita-
Autor(es): dc.creatorPereira Lima Brigagdo, Maisa Ribeiro-
Autor(es): dc.creatorArdijo Paula, Fernanda Borges de-
Data de aceite: dc.date.accessioned2022-02-22T00:09:30Z-
Data de disponibilização: dc.date.available2022-02-22T00:09:30Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2019-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1248/bpb.b18-00952-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196455-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196455-
Descrição: dc.descriptionDifferent Passiflora species have been appointed as a promising herbal medicine due to antioxidant properties; however, their effect on oxidative process induced by diabetes is still controversial. We aimed to evaluate effects of hydroethanolic extract 70% from P. edulis leaf on biochemical blood markers, collagen glycation, production of oxidant species and platelet aggregation in diabetic rats. The phytochemical analysis of the extract was performed by dereplication using LC coupled to the Photodiode Array Detector and Mass Spectrometer detector. Male Wistar rats were assigned to the control group and groups treated with alloxan (150 mg/kg) intraperitoneally, extract (200 mg/kg/d, for 90d) and combination of alloxan and extract. The phytochemical analysis suggested the presence of flavonoids C-glycosides in the extract. The diabetic animals treated with the extract presented improvement in glycaemic control, reduced glycation collagen, levels of non-high density lipoprotein (non-HDL) cholesterol, total cholesterol and creatinine, production of oxidant species and aggregation in platelet in relation to diabetic animals non-treated. Our results showed that P. edulis leaf extract presents a health benefit to the diabetic state, preventing the appearance of its complications. Its effect can be associated with flavonoids, among which is the flavonoid C-glycoside isoorientin.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
Descrição: dc.descriptionUniv Fed Alfenas, Coll Pharmaceut Sci, Dept Clin Anal & Toxicol, BR-37130001 Alfenas, MG, Brazil-
Descrição: dc.descriptionFed Univ Maranhdo, Dept Chem, BR-65080805 Sao Luis, MA, Brazil-
Descrição: dc.descriptionState Univ Sao Paulo, Inst Biosci, Coastal Campus Sao Vicente, BR-11380972 Sao Vicente, SP, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Coll Pharmaceut Sci, Dept Clin Anal & Toxicol, BR-05508000 Sao Paulo, SP, Brazil-
Descrição: dc.descriptionUniv Fed Alfenas, Inst Biomed Sci, BR-37130001 Alfenas, MG, Brazil-
Descrição: dc.descriptionJose Rosario Vellano Univ, Alfenas, MG, Brazil-
Descrição: dc.descriptionSpanish Natl Canc Res Ctr CNIO, Madrid 28029, Spain-
Descrição: dc.descriptionState Univ Sao Paulo, Inst Biosci, Coastal Campus Sao Vicente, BR-11380972 Sao Vicente, SP, Brazil-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format169-174-
Idioma: dc.languageen-
Publicador: dc.publisherPharmaceutical Soc Japan-
Relação: dc.relationBiological & Pharmaceutical Bulletin-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectPassiflora edulis-
Palavras-chave: dc.subjectdiabetes mellitus-
Palavras-chave: dc.subjectplatelet aggregation-
Palavras-chave: dc.subjectbiochemical marker-
Palavras-chave: dc.subjectquantification-
Palavras-chave: dc.subjectisoorientin-
Título: dc.titlePassiflora edulis Leaf Extract: Evidence of Antidiabetic and Antiplatelet Effects in Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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