In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorCosta, Nathalia Orlandini-
Autor(es): dc.creatorBorges, Lorena Ireno-
Autor(es): dc.creatorCavalcanti, Liara Freitas-
Autor(es): dc.creatorMontagnini, Bruno Garcia-
Autor(es): dc.creatorAnselmo Franci, Janete Aparecida-
Autor(es): dc.creatorKiss, Ana Carolina Inhasz [UNESP]-
Autor(es): dc.creatorGerardin, Daniela Cristina Ceccatto-
Data de aceite: dc.date.accessioned2022-02-22T00:09:26Z-
Data de disponibilização: dc.date.available2022-02-22T00:09:26Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2019-12-22-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/jat.3922-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196431-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196431-
Descrição: dc.descriptionTriclocarban (TCC) is an antimicrobial compound widely used in personal care products such as soaps, toothpaste, and shampoo. This agent is incompletely removed by wastewater treatment and represents an environmental contaminant. Recent studies have shown that TCC is associated with some endocrine disruptions. The aim of the present study was to evaluate if TCC exposure during critical periods of development (gestation and lactation) could lead to adverse effects on reproductive and behavior parameters of female offspring. Pregnant female Wistar rats were divided into four groups (n = 8-11/group): Control; TCC 0.3 mg/kg (TCC 0.3); TCC 1.5 mg/kg; TCC 3.0 mg/kg (TCC 3.0); and treated daily by oral gavage from gestational day 0 to lactational day 21. The female pups (F1 generation) were weaned on post-natal day 21 and included in the study. No litter-mates were used for the same group. There was a decrease in estradiol levels in the TCC 0.3 and TCC 3.0 groups. Moreover, there was a decrease in progesterone levels and an increase in pre-implantation loss in the TCC 3.0 group in adulthood. It is suggested, in this study, that the decrease in progesterone biosynthesis could interfere with implantation process. The exposure window to TCC is an important factor, as we found alterations only in the offspring.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundacao Araucaria-
Descrição: dc.descriptionUniv Estadual Londrina, Dept Physiol Sci, Londrina, Parana, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Dept Morphol Estomatol & Physiol, Sao Paulo, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dept Physiol, Botucatu Biosci Inst, Sao Paulo, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Dept Physiol, Botucatu Biosci Inst, Sao Paulo, Brazil-
Formato: dc.format504-514-
Idioma: dc.languageen-
Publicador: dc.publisherWiley-Blackwell-
Relação: dc.relationJournal Of Applied Toxicology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectbehavior-
Palavras-chave: dc.subjectendocrine disruptor-
Palavras-chave: dc.subjectfertility-
Palavras-chave: dc.subjectmaternal exposure-
Palavras-chave: dc.subjectprogesterone-
Título: dc.titleIn utero and lactational exposure to triclocarban: reproductive effects on female rat offspring-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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