Quantification of Trans-Resveratrol-Loaded Solid Lipid Nanoparticles by a Validated Reverse-Phase HPLC Photodiode Array

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniv Tiradentes Unit-
Autor(es): dc.contributorCREA Res Ctr Food & Nutr-
Autor(es): dc.contributorUniv Vienna-
Autor(es): dc.contributorBulgarian Acad Sci-
Autor(es): dc.contributorUniv Napoli Federico II-
Autor(es): dc.contributorUniv Coimbra FFUC-
Autor(es): dc.contributorUniv Minho-
Autor(es): dc.creatorRigon, Roberta B. [UNESP]-
Autor(es): dc.creatorFachinetti, Naiara [UNESP]-
Autor(es): dc.creatorSeverino, Patricia-
Autor(es): dc.creatorDurazzo, Alessandra-
Autor(es): dc.creatorLucarini, Massimo-
Autor(es): dc.creatorAtanasov, Atanas G.-
Autor(es): dc.creatorEl Mamouni, Soukaina-
Autor(es): dc.creatorChorilli, Marlus [UNESP]-
Autor(es): dc.creatorSantini, Antonello-
Autor(es): dc.creatorSouto, Eliana B.-
Data de aceite: dc.date.accessioned2022-02-22T00:09:21Z-
Data de disponibilização: dc.date.available2022-02-22T00:09:21Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2019-11-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/app9224961-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196407-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196407-
Descrição: dc.descriptionA new method based on reverse-phase HPLC combined with photodiode array (PDA) was developed to quantify the release of trans-resveratrol (tRES) from solid lipid nanoparticles (SLN). The mobile phase was composed of 75:0:25 (V/V) water/methanol/acetonitrile at 0-3.5 min, 32.5:30.0:37.5 (V/V) water/methanol/acetonitrile at 3.6-5.8 min, and 75:0:25 (V/V) water/methanol/acetonitrile at 5.9-10 min. The flow rate was set at 1.0mL/min, and tRES was detected at the wavelength of 306.6 nm. A concentration range of 1-100 mu g/mL was used to obtain the linear calibration curve. SLN were produced by ultrasound technique to load 0.1% (wt/wt) of tRES, and the in vitro release of the drug was run in modified Franz diffusion cells. The mean recovery of tRES was found to be 96.84 +/- 0.32%. The intra-assay and inter-assay coefficients of variation were less than 5%. The proposed method was applied to in vitro permeability studies, and the Weibull model was found to be the one that best fits the tRES release, which is characterized by a simultaneous lipid chain relaxation and erosion during drug release.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionPortuguese Science and Technology Foundation (FCT/MCT)-
Descrição: dc.descriptionEuropean Funds (PRODER/COMPETE)-
Descrição: dc.descriptionFEDER-
Descrição: dc.descriptionproject: Nutraceutica come supporto nutrizionale nel paziente oncologico-
Descrição: dc.descriptionUniv Estadual Paulista, Sch Pharmaceut Sci Araraquara, Dept Drugs & Med, Rod Araraquara Jau,Km 1, BR-14801902 Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Tiradentes Unit, Tiradentes Inst, Av Murilo Dantas 300, BR-49010390 Aracaju, SE, Brazil-
Descrição: dc.descriptionCREA Res Ctr Food & Nutr, Via Ardeatina 546, I-00178 Rome, Italy-
Descrição: dc.descriptionUniv Vienna, Dept Pharmacognosy, A-1090 Vienna, Austria-
Descrição: dc.descriptionBulgarian Acad Sci, Inst Neurobiol, 23 Acad G Bonchev Str, Sofia 1113, Bulgaria-
Descrição: dc.descriptionUniv Napoli Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy-
Descrição: dc.descriptionUniv Coimbra FFUC, Fac Pharm, Dept Pharmaceut Technol, P-3000548 Coimbra, Portugal-
Descrição: dc.descriptionUniv Minho, CEB Ctr Biol Engn, Campus Gualtar, P-4710057 Braga, Portugal-
Descrição: dc.descriptionUniv Estadual Paulista, Sch Pharmaceut Sci Araraquara, Dept Drugs & Med, Rod Araraquara Jau,Km 1, BR-14801902 Araraquara, SP, Brazil-
Descrição: dc.descriptionEuropean Funds (PRODER/COMPETE): M-ERA-NET-0004/2015-PAIRED-
Descrição: dc.descriptionproject: Nutraceutica come supporto nutrizionale nel paziente oncologico: CUP: B83D18000140007-
Formato: dc.format15-
Idioma: dc.languageen-
Publicador: dc.publisherMdpi-
Relação: dc.relationApplied Sciences-basel-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjecttrans-resveratrol-
Palavras-chave: dc.subjectnanotechnology-
Palavras-chave: dc.subjectsolid lipid nanoparticles-
Palavras-chave: dc.subjecthigh-performance liquid chromatography-
Título: dc.titleQuantification of Trans-Resveratrol-Loaded Solid Lipid Nanoparticles by a Validated Reverse-Phase HPLC Photodiode Array-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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