Combined effects of exercise training and high doses of anabolic steroids on cardiac autonomic modulation and ventricular repolarization properties in rats

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniv Fed Juiz de Fora-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniv Fed Triangulo Mineiro-
Autor(es): dc.creatorMarocolo, Moacir-
Autor(es): dc.creatorKatayama, Pedro L. [UNESP]-
Autor(es): dc.creatorMeireles, Anderson-
Autor(es): dc.creatorBarbosa Neto, Octavio-
Data de aceite: dc.date.accessioned2022-02-22T00:09:10Z-
Data de disponibilização: dc.date.available2022-02-22T00:09:10Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2019-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1139/cjpp-2019-0286-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196341-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196341-
Descrição: dc.descriptionSeveral studies have reported that high doses of synthetic anabolic androgenic steroids (AAS) can have serious negative effects on health, including the cardiovascular system. The aim of this study was to evaluate the combined effects of AAS and exercise training on ventricular repolarization and cardiac autonomic modulation in rats. Male Wistar rats were allocated into 4 groups: sedentary rats treated with vehicle, sedentary rats treated with nandrolone decanoate, swimming-trained rats treated with vehicle, and swimming-trained rats treated with nandrolone decanoate. Ventricular repolarization was evaluated by electrocardiographic analysis of QT interval and QT dispersion. Cardiac autonomic modulation was assessed by heart rate variability. Our results show that AAS increased QT interval and QT dispersion in sedentary rats treated with nandrolone decanoate as compared to sedentary rats treated with vehicle, indicating AAS-induced ventricular repolarization abnormalities. When rats treated with nandrolone decanoate were subjected to concomitant exercise training, ventricular repolarization was normalized. On the other hand, AAS-induced reduction in cardiac parasympathetic modulation was not prevented by exercise training. In conclusion, AAS produced cardiac autonomic dysfunction and ventricular repolarization disturbances in rats. Combining an exercise training protocol during the AAS treatment attenuated the ventricular repolarization abnormalities and did not prevent cardiac autonomic dysfunction.-
Descrição: dc.descriptionUniv Fed Juiz de Fora, Dept Physiol, Physiol & Human Performance Res Grp, Juiz De Fora, MG, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Sch Dent, Dept Physiol & Pathol, Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Fed Triangulo Mineiro, Sport Sci Dept, Uberaba, MG, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Sch Dent, Dept Physiol & Pathol, Araraquara, SP, Brazil-
Formato: dc.format1185-1192-
Idioma: dc.languageen-
Publicador: dc.publisherCanadian Science Publishing-
Relação: dc.relationCanadian Journal Of Physiology And Pharmacology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectelectrocardiography-
Palavras-chave: dc.subjectexercise training-
Palavras-chave: dc.subjectheart rate variability-
Palavras-chave: dc.subjectnandrolone decanoate-
Palavras-chave: dc.subjectspectral analysis-
Título: dc.titleCombined effects of exercise training and high doses of anabolic steroids on cardiac autonomic modulation and ventricular repolarization properties in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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