Hematopoietic Chimera in a Male Blood Donor and His Dizygotic Twin Sister

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorMed Sch Sao Jose do Rio Preto FAMERP-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorHosp Naval Marcilio Dias-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorMiola, Marcos P.-
Autor(es): dc.creatorLopes, Alessandro G. [UNESP]-
Autor(es): dc.creatorSilva, Alessandra P.-
Autor(es): dc.creatorGomes, Edney G. C.-
Autor(es): dc.creatorMachado, Leticia A. F.-
Autor(es): dc.creatorVeloso, Wanessa A.-
Autor(es): dc.creatorCosta, Carlos A.-
Autor(es): dc.creatorFachini, Roberta M.-
Autor(es): dc.creatorRicci Junior, Octavio-
Autor(es): dc.creatorBrandao de Mattos, Cinara C.-
Autor(es): dc.creatorMattos, Luiz Carlos de-
Data de aceite: dc.date.accessioned2022-02-22T00:09:06Z-
Data de disponibilização: dc.date.available2022-02-22T00:09:06Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2019-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1159/000495583-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196325-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196325-
Descrição: dc.descriptionTwin hematopoietic chimera in humans is a phenomenon that was discovered accidentally and the prevalence of which remains unclear. The resolution of chimera cases requires studying family medical records, data analysis, and investigations of hematopoietic cells and cells from other tissues. The interactions among ABO, Lewis, and secretor histo-blood group systems are explored to resolve cases of hematopoietic chimera. Here we report a rare case of hematopoietic chimera where twins present a mixed field reaction in the ABO, Rh, and Kidd red blood cell phenotyping. Using red blood cells separated from the mixed field as well as molecular approaches and investigations of family members, we identify inconsistent genotypes with the Mendelian inheritance pattern when comparing the peripheral blood with the buccal epithelium of the male twin and his twin sister. Analysis of the ABO, Lewis, and secretor phenotypes, and genomic DNA from buccal epithelium showed the genotypes ABO*A1.01/ABO*B.01 and FUT2*01N.02/FUT2*01N.02 in the male twin and the genotypes ABO*O.01.01/ABO*O.01.02 and FUT2*01/FUT2*01 in the female twin. The results of the HLA-DRB1 genotyping showed inconsistency between the male and his twin sister. We conclude that the serological analyses combined with molecular approaches used in this study are good tools to resolve cases of hematopoietic chimera. (C) 2019 S. Karger AG, Basel-
Descrição: dc.descriptionMed Sch Sao Jose do Rio Preto FAMERP, Dept Mol Biol, Ave Brigadeiro Faria Lima 5416, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil-
Descrição: dc.descriptionInst Biociencias Letras Ciencias Exatas IBILCE, Dept Biol, Campus Sao Jose do Rio Preto, Sao Jose Do Rio Preto, Brazil-
Descrição: dc.descriptionHosp Naval Marcilio Dias, Dept Special Serv, Hemotherapy Serv, Rio De Janeiro, Brazil-
Descrição: dc.descriptionMed Sch Sao Jose do Rio Preto FAMERP, Dept Med, Sao Jose Do Rio Preto, Brazil-
Descrição: dc.descriptionInst Biociencias Letras Ciencias Exatas IBILCE, Dept Biol, Campus Sao Jose do Rio Preto, Sao Jose Do Rio Preto, Brazil-
Formato: dc.format276-281-
Idioma: dc.languageen-
Publicador: dc.publisherKarger-
Relação: dc.relationTransfusion Medicine And Hemotherapy-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectChimerism-
Palavras-chave: dc.subjectDizygotic twins-
Palavras-chave: dc.subjectBlood groups-
Palavras-chave: dc.subjectPhenotyping-
Palavras-chave: dc.subjectMolecular analysis-
Título: dc.titleHematopoietic Chimera in a Male Blood Donor and His Dizygotic Twin Sister-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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