Chemical and Biological Characteristics of Antimicrobial alpha-Helical Peptides Found in Solitary Wasp Venoms and Their Interactions with Model Membranes

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorButantan Inst-
Autor(es): dc.contributorUniv Toyama-
Autor(es): dc.creatorSantos Cabrera, Marcia Perez dos [UNESP]-
Autor(es): dc.creatorRangel, Marisa-
Autor(es): dc.creatorNeto, Joao Ruggiero [UNESP]-
Autor(es): dc.creatorKonno, Katsuhiro-
Data de aceite: dc.date.accessioned2022-02-22T00:09:00Z-
Data de disponibilização: dc.date.available2022-02-22T00:09:00Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2019-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/toxins11100559-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196287-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196287-
Descrição: dc.descriptionSolitary wasps use their stinging venoms for paralyzing insect or spider prey and feeding them to their larvae. We have surveyed bioactive substances in solitary wasp venoms, and found antimicrobial peptides together with some other bioactive peptides. Eumenine mastoparan-AF (EMP-AF) was the first to be found from the venom of the solitary eumenine wasp Anterhynchium flavomarginatum micado, showing antimicrobial, histamine-releasing, and hemolytic activities, and adopting an alpha-helical secondary structure under appropriate conditions. Further survey of solitary wasp venom components revealed that eumenine wasp venoms contained such antimicrobial alpha-helical peptides as the major peptide component. This review summarizes the results obtained from the studies of these peptides in solitary wasp venoms and some analogs from the viewpoint of (1) chemical and biological characterization; (2) physicochemical properties and secondary structure; and (3) channel-like pore-forming properties.-
Descrição: dc.descriptionJSPS KAKENHI-
Descrição: dc.descriptionMinistry of Education, Culture, Sports, Science and Technology (MEXT) of Japan-
Descrição: dc.descriptionSao Paulo State Univ, IBILCE, Dept Phys, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil-
Descrição: dc.descriptionButantan Inst, Immunopathol Lab, BR-05503900 Sao Paulo, SP, Brazil-
Descrição: dc.descriptionUniv Toyama, Inst Nat Med, 2630 Sugitani, Toyama 9300194, Japan-
Descrição: dc.descriptionSao Paulo State Univ, IBILCE, Dept Phys, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil-
Descrição: dc.descriptionJSPS KAKENHI: 15K07805-
Formato: dc.format18-
Idioma: dc.languageen-
Publicador: dc.publisherMdpi-
Relação: dc.relationToxins-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectsolitary wasp-
Palavras-chave: dc.subjectvenom-
Palavras-chave: dc.subjectantimicrobial peptide-
Palavras-chave: dc.subjectlinear cationic alpha-helical peptide-
Palavras-chave: dc.subjectamphipathic alpha-helix structure-
Palavras-chave: dc.subjectchannel-like pore-forming activity-
Título: dc.titleChemical and Biological Characteristics of Antimicrobial alpha-Helical Peptides Found in Solitary Wasp Venoms and Their Interactions with Model Membranes-
Aparece nas coleções:Repositório Institucional - Unesp

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