Detoxification, oxidative stress, and cytogenotoxicity of crack cocaine in the brown mussel Perna perna

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Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorUniv Santa Cecilia-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorCIETEC IPEN-
Autor(es): dc.creatorBarbosa Ortega, Andressa dos Santos-
Autor(es): dc.creatorMaranho, Luciane Alves-
Autor(es): dc.creatorNobre, Caio Rodrigues [UNESP]-
Autor(es): dc.creatorMoreno, Beatriz Barbosa-
Autor(es): dc.creatorGuimaraes, Rafael Sole-
Autor(es): dc.creatorLebre, Daniel Temponi-
Autor(es): dc.creatorSouza Abessa, Denis Moledo de [UNESP]-
Autor(es): dc.creatorRibeiro, Daniel Araki-
Autor(es): dc.creatorSeabra Pereira, Camilo Dias-
Data de aceite: dc.date.accessioned2022-02-22T00:08:53Z-
Data de disponibilização: dc.date.available2022-02-22T00:08:53Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2019-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11356-018-1600-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196243-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196243-
Descrição: dc.descriptionThe presence of cocaine and its metabolites and by-products has been identified in different aquatic matrices, making crack cocaine the target of recent studies. The aim of this study was to evaluate the sublethal effects of crack on the brown mussel Perna perna. Mussels were exposed to three concentrations of crack cocaine (0.5, 5.0, and 50.0 mu g L-1) for 168 h. Gills, digestive glands, and hemolymph were extracted and analyzed after three different exposure times using a suite of biomarkers (EROD, DBF, GST, GPX, LPO, DNA damage, ChE, and lysosomal membrane stability [LMS]). After 48 and 96 h of exposure, EROD, DBF, GST, GPX activities and DNA strand breaks in the gills increased significantly after 48 and 96 h of exposure. Alterations in LMS were also observed in the mussels exposed to all crack concentrations after 96 and 168 h. Our results demonstrated that crack cocaine is metabolized by CYP-like and GST activities in the gills. GPX was not able to prevent primary genetic damage, and cytotoxic effects in the hemocytes were also observed in a dose- and time-dependent response. Our study shows that the introduction of illicit drugs into coastal ecosystems must be considered a threat to marine organisms.-
Descrição: dc.descriptionFundacao deAmparo a Pesquisa do Estado de Sao Paulo-
Descrição: dc.descriptionUniv Fed Sao Paulo, Dept Ciencias Mar, Rua Maria Maximo 168, BR-11030100 Santos, Brazil-
Descrição: dc.descriptionUniv Santa Cecilia, Lab Ecotoxicol, Rua Oswaldo Cruz 266, BR-11045907 Santos, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Inst Biociencias, Campus Litoral Paulista,Infante Dom Henrique S-N, BR-11330900 Sao Vicente, Brazil-
Descrição: dc.descriptionCIETEC IPEN, CEMSA Ctr Espectrometria Massas Aplicada, Av Prof Lineu Prestes 2242,Salas 112 & 113, BR-05508000 Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Fed Sao Paulo, Dept Biociencias, Av Ana Costa 95, BR-11060001 Santos, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Inst Biociencias, Campus Litoral Paulista,Infante Dom Henrique S-N, BR-11330900 Sao Vicente, Brazil-
Descrição: dc.descriptionFundacao deAmparo a Pesquisa do Estado de Sao Paulo: 2015/17329-0-
Formato: dc.format27569-27578-
Idioma: dc.languageen-
Publicador: dc.publisherSpringer-
Relação: dc.relationEnvironmental Science And Pollution Research-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectIllicit drugs-
Palavras-chave: dc.subjectCrack cocaine-
Palavras-chave: dc.subjectBiomarkers-
Palavras-chave: dc.subjectMarine organism-
Palavras-chave: dc.subjectAdverse effects-
Palavras-chave: dc.subjectBivalves-
Título: dc.titleDetoxification, oxidative stress, and cytogenotoxicity of crack cocaine in the brown mussel Perna perna-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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