DBBM shows no signs of resorption under inflammatory conditions. An experimental study in the mouse calvaria

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Autor(es): dc.contributorMed Univ Vienna-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorLudwig Boltzmann Inst Clin & Expt Traumatol-
Autor(es): dc.contributorAustrian Cluster Tissue Regenerat-
Autor(es): dc.contributorUniv Bern-
Autor(es): dc.contributorUniv Chile-
Autor(es): dc.creatorKuchler, Ulrike-
Autor(es): dc.creatorSantos, Gabriel Mulinari dos [UNESP]-
Autor(es): dc.creatorHeimel, Patrick-
Autor(es): dc.creatorStaehli, Alexandra-
Autor(es): dc.creatorStrauss, Franz Josef-
Autor(es): dc.creatorTangl, Stefan-
Autor(es): dc.creatorGruber, Reinhard-
Data de aceite: dc.date.accessioned2022-02-22T00:08:48Z-
Data de disponibilização: dc.date.available2022-02-22T00:08:48Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2019-09-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/clr.13538-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/196221-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/196221-
Descrição: dc.descriptionObjectives Deproteinized bovine bone mineral (DBBM) is not resorbable. However, the behavior of DBBM under inflammatory conditions remains unclear. Aim of the study was therefore to evaluate the resorption of DBBM under local inflammatory conditions in vivo using the calvarial osteolysis model. Methods In thirty adult BALB/c mice, DBBM was implanted into the space between the elevated soft tissue and the calvarial bone. Inflammation was induced either by lipopolysaccharides (LPS) injection or by polyethylene particles (Ceridust) mixed with DBBM. Three modalities were randomly applied (n = 10 each): (a) DBBM alone (control), (b) DBBM + LPS, and (c) DBBM + polyethylene particles (Ceridust). Mice were euthanized on day fourteen, and each calvarium was subjected to histological and mu CT analysis. Primary outcome was the size distribution of the DBBM particles. Secondary outcome was the surface erosion of the calvarial bone. Results Histological and mu CT analysis revealed that the size distribution and the volume of DBBM particles in the augmented site were similar between DBBM alone and the combinations with LPS or polyethylene particles. Moreover, histological evaluation showed no signs of erosions of DBBM particles under inflammatory conditions. mu CT analysis and histology further revealed that LPS and the polyethylene particles, but not the DBBM alone, caused severe erosions of the calvarial bone as indicated by large voids representing the massive compensatory new immature woven bone formation on the endosteal surface. Conclusions Local calvarial bone but not the DBBM particles undergo severe resorption and subsequent new bone formation under inflammatory conditions in a mouse model.-
Descrição: dc.descriptionOsteology Foundation-
Descrição: dc.descriptionAustrian Science Fund-
Descrição: dc.descriptionMed Univ Vienna, Univ Clin Dent, Dept Oral Surg, Vienna, Austria-
Descrição: dc.descriptionUniv Estadual Paulista, Aracatuba Dent Sch, Dept Oral Surg, Aracatuba, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Aracatuba Dent Sch, Integrated Clin, Aracatuba, Brazil-
Descrição: dc.descriptionMed Univ Vienna, Univ Clin Dent, Karl Donath Lab, Core Facil Hard Tissue & Biomat Res, Vienna, Austria-
Descrição: dc.descriptionMed Univ Vienna, Univ Clin Dent, Dept Oral Biol, Vienna, Austria-
Descrição: dc.descriptionLudwig Boltzmann Inst Clin & Expt Traumatol, Vienna, Austria-
Descrição: dc.descriptionAustrian Cluster Tissue Regenerat, Vienna, Austria-
Descrição: dc.descriptionUniv Bern, Sch Dent Med, Dept Periodontol, Bern, Switzerland-
Descrição: dc.descriptionUniv Chile, Sch Dent, Dept Conservat Dent, Santiago, Chile-
Descrição: dc.descriptionUniv Estadual Paulista, Aracatuba Dent Sch, Dept Oral Surg, Aracatuba, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Aracatuba Dent Sch, Integrated Clin, Aracatuba, Brazil-
Descrição: dc.descriptionOsteology Foundation: 14-126-
Descrição: dc.descriptionAustrian Science Fund: 4072-B28-
Formato: dc.format10-17-
Idioma: dc.languageen-
Publicador: dc.publisherWiley-Blackwell-
Relação: dc.relationClinical Oral Implants Research-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectbone regeneration-
Palavras-chave: dc.subjectbone substitutes-
Palavras-chave: dc.subjectcalvaria-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectmice-
Palavras-chave: dc.subjectosteoclasts-
Título: dc.titleDBBM shows no signs of resorption under inflammatory conditions. An experimental study in the mouse calvaria-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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