Expression of the nonclassical HLA-G and HLA-E molecules in laryngeal lesions as biomarkers of tumor invasiveness

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniv Fed Rio Grande do Norte-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.creatorSilva, Tarsia G.-
Autor(es): dc.creatorCrispim, Janaina C. O.-
Autor(es): dc.creatorMiranda, Fabiana A.-
Autor(es): dc.creatorHassumi, Marcela K.-
Autor(es): dc.creatorMello, Julia M. Y. de-
Autor(es): dc.creatorSimoes, Renata T.-
Autor(es): dc.creatorSouto, Francisco-
Autor(es): dc.creatorSoares, Edson G.-
Autor(es): dc.creatorDonadi, Eduardo A.-
Autor(es): dc.creatorSoares, Christiane P. [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:08:00Z-
Data de disponibilização: dc.date.available2022-02-22T00:08:00Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2011-12-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/195995-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/195995-
Descrição: dc.descriptionIntroduction: HLA-G and HLA-E are two nonclassical class I molecules, which have been well recognized as modulators of innate and adaptive immune responses, and the expression of these molecules in virus infected cells has been associated with subversion of the immune response. Objective: In this study we performed a cross-sectional study, systematically comparing the expression of HLA-G and HLA-E in benign, premalignant and malignant laryngeal lesions, correlating with demographic and clinical variables and with the presence of high-risk and low-risk HPV types. Materials and methods: Laryngeal lesions were collected from 109 patients and stratified into 27 laryngeal papillomas, 17 dysplasias, 10 in situ laryngeal carcinomas, 27 laryngeal carcinomas without metastases, 28 laryngeal carcinomas with metastasis along with their respective draining cervical lymph nodes, and 10 normal larynx specimens. The expression of HLA-G and HLA-E molecules was determined by immunohistochemistry. HPV DNA detection and typing was performed using generic and specific primers. Results: HLA nonclassical molecules showed a distinct distribution pattern, according to the larynx lesion grade. HLA-G expression increased in benign and premalignant lesions, and gradually decreased in invasive carcinomas and in respective draining cervical lymph nodes. Conversely, HLA-E expression increased as far as lesion grade increased, including increased molecule expression in the draining lymph nodes of malignant lesions. Only 17 (15.6%) patients were HPV DNA positive. Conclusions: Overexpression of HLA-E and underexpression of HLA-G appear to be good markers for malignant larynx lesion.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUNESP, Fac Pharmaceut Sci, Lab Cytol & Cell Biol, Sch Pharmaceut Sci,Dept Clin Anal, BR-14801902 Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Fed Rio Grande do Norte, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, Natal, RN, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Fac Med Ribeirao Preto, Div Clin Immunol, Dept Med, BR-05508 Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Pathol, BR-05508 Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Fed Mato Grosso, Dept Internal Med, Cuiaba, Mato Grosso, Brazil-
Descrição: dc.descriptionUNESP, Fac Pharmaceut Sci, Lab Cytol & Cell Biol, Sch Pharmaceut Sci,Dept Clin Anal, BR-14801902 Araraquara, SP, Brazil-
Formato: dc.format1487-1497-
Idioma: dc.languageen-
Publicador: dc.publisherF Hernandez-
Relação: dc.relationHistology And Histopathology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectHLA-G-
Palavras-chave: dc.subjectHLA-E-
Palavras-chave: dc.subjectLaryngeal lesions-
Palavras-chave: dc.subjectHPV-
Palavras-chave: dc.subjectBiomarkers-
Título: dc.titleExpression of the nonclassical HLA-G and HLA-E molecules in laryngeal lesions as biomarkers of tumor invasiveness-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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