Humoral immune response, bacterial recovery and time lesions in mice geneticaly selected for high and low antibody production and in outbreed Balb/c mice face to Leptospira interrogans sorovar icterohaemorrhagiae.

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorMarinho, W.-
Autor(es): dc.creatorLangoni, H.-
Autor(es): dc.creatorOliveira, S. L.-
Autor(es): dc.creatorCarreira, R.-
Autor(es): dc.creatorPerri, SHV-
Autor(es): dc.creatorLuvizoto, M. C.-
Data de aceite: dc.date.accessioned2022-02-22T00:06:45Z-
Data de disponibilização: dc.date.available2022-02-22T00:06:45Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2003-01-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/195736-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/195736-
Descrição: dc.descriptionThe aim of the present work was to. evaluate the association among the kinetics of humoral immune response, the recovery of viable leptospiras and the intensity of the tissue lesions in mice selected for high (H) and low (L) production of antibodies (selection IV-A) and in mice from the outbreed Balb/c line, inoculated with pathogenic Leptospira interrogans serovar icterohaemorrhagiae. The H and L lines showed modifications in some steps of the immune response, mainly in relation to the macrophagic activity, representing extreme phenotypes found in heterogeneous natural populations. Mice were sacrificed in eight moments after the infection. Analysis of the results revealed that from the 7th day after the infection, on line H mice presented antibodies titles significantly higher as compared to the L line mice, maintaining the multispecific effect Balb/c line mice showed intermediate results between the two lines. Antibodies production worked as a limiting factor to the infection, because when a greater leptospiras recovery was obtained, at the initial phase of the infection, the titles of antibodies were elevated. Inflammatory and degenerative process led to similar lesions in the organs of infected mice. Only a variation in the degree of tissue compromising was observed according to the line. H line mice showed more extensive lesions than L and Balb/c lines mice. For the Balb/c line mice, the lesions were moderate. As a rule, H and Balb/c mice lines showed a Th2 profile of immune response, with higher indexes of antibody production and gravity of the lesions, while L line mice presented a Th1 profile of immune response.-
Descrição: dc.descriptionUNESP, Microbiol Lab, Dept Apoio Prod & Saude Anim FOA, BR-16050680 Aracatuba, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Higiene & Sau Publ, NUPEZO, BR-18618000 Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil-
Descrição: dc.descriptionUNESP, Dept Clin & Chirugia FOA, Disciplina Patol, BR-16050680 Aracatuba, SP, Brazil-
Descrição: dc.descriptionUNESP, Microbiol Lab, Dept Apoio Prod & Saude Anim FOA, BR-16050680 Aracatuba, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Dept Higiene & Sau Publ, NUPEZO, BR-18618000 Botucatu, SP, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil-
Descrição: dc.descriptionUNESP, Dept Clin & Chirugia FOA, Disciplina Patol, BR-16050680 Aracatuba, SP, Brazil-
Formato: dc.format5-12-
Idioma: dc.languagees-
Publicador: dc.publisherRevista Pesquisa Veterinaria Brasileira-
Relação: dc.relationPesquisa Veterinaria Brasileira-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectleptospirosis-
Palavras-chave: dc.subjecthumoral immune response-
Palavras-chave: dc.subjectbacterial recovery-
Palavras-chave: dc.subjectlesions-
Palavras-chave: dc.subjectmice genetically selected-
Palavras-chave: dc.subjectBalb/c-
Título: dc.titleHumoral immune response, bacterial recovery and time lesions in mice geneticaly selected for high and low antibody production and in outbreed Balb/c mice face to Leptospira interrogans sorovar icterohaemorrhagiae.-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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