Natural killer activity in a medium-term multi-organ bioassay for carcinogenesis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorSpinardi, ALT-
Autor(es): dc.creatorKaneno, R.-
Autor(es): dc.creatorRodrigues, MAM-
Autor(es): dc.creatorSalvadori, DMF-
Autor(es): dc.creatorRocha, N. S.-
Autor(es): dc.creatorBarbisan, L. F.-
Autor(es): dc.creatorRibeiro, L. R.-
Autor(es): dc.creatorCamargo, JLV de-
Data de aceite: dc.date.accessioned2022-02-22T00:06:36Z-
Data de disponibilização: dc.date.available2022-02-22T00:06:36Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued1999-01-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/195683-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/195683-
Descrição: dc.descriptionNatural killer (NK) cell activity was evaluated after the initiation and promotion steps in a medium-term multi-organ bioassay for carcinogenesis. NK cell activity was assessed in vitro by Cr-51 release assay at the 4th and 30th weeks of the experiment. Male Wistar rats were sequentially initiated with N-diethylnitrosamine (DEN i.p.), N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN drinking water), N-methyl-N-nitrosourea (MNU i.p.), dihydroxy-di-N-propylnitrosamine (DHPN drinking water) and N,N'-dimethylhydrazine (DMH s.c.) at subcarcinogenic doses for 4 weeks (DMBDD initiation). One group was evaluated at the 4th week and the other was maintained without any further treatment until the 30th week. Two initiated groups were exposed through the diet to 2-acetylaminofluorene (2-AAF) or phenobarbital (PB), from the 6th until the 30th week, Five additional groups were studied to evaluate the effects of each initiator on NK activity. All groups submitted to initiation only, initiation plus promotion, or promotion only, developed significantly more preneoplastic lesions than the untreated control group. The main target organs for tumor development in the initiated animals n ere the liver and the colon, irrespective of treatment with 2-AAF or PB. NK cell activity was not affected bal exposure to genotoxic carcinogens after initiation, at the 4th week. Treatments only with PB or 2-AAF did not change NK cell activity, However, decreased NK cell activity was registered in the group only initiated with DMBDD and in the group given DMBDD+2-AAF. This late depression of NK cell activity at the 30th week could be related to the production of suppressing molecules by the tumor cells.-
Descrição: dc.descriptionUNESP, Fac Med, Dept Pathol, BR-18618000 Botucatu, SP, Brazil-
Descrição: dc.descriptionUNESP, Fac Med Vet, Dept Pathol, BR-18618000 Botucatu, SP, Brazil-
Descrição: dc.descriptionUNESP, Dept Microbiol & Immunol, BR-18618000 Botucatu, SP, Brazil-
Descrição: dc.descriptionUNESP, Inst Biosci, Dept Morphol, BR-18618000 Botucatu, SP, Brazil-
Descrição: dc.descriptionUNESP, Fac Med, Dept Pathol, BR-18618000 Botucatu, SP, Brazil-
Descrição: dc.descriptionUNESP, Fac Med Vet, Dept Pathol, BR-18618000 Botucatu, SP, Brazil-
Descrição: dc.descriptionUNESP, Dept Microbiol & Immunol, BR-18618000 Botucatu, SP, Brazil-
Descrição: dc.descriptionUNESP, Inst Biosci, Dept Morphol, BR-18618000 Botucatu, SP, Brazil-
Formato: dc.format101-107-
Idioma: dc.languageen-
Publicador: dc.publisherJapanese Cancer Assoc-
Relação: dc.relationJapanese Journal Of Cancer Research-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectNK cell activity-
Palavras-chave: dc.subjectimmune response-
Palavras-chave: dc.subjectmulti-organ carcinogenesis-
Palavras-chave: dc.subjectchemical carcinogens-
Título: dc.titleNatural killer activity in a medium-term multi-organ bioassay for carcinogenesis-
Tipo de arquivo: dc.typelivro digital-
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