Clinical and ultrasound variables for early diagnosis of septic acute kidney injury in bitches with pyometra

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de Viçosa (UFV)-
Autor(es): dc.contributorUniv Franca UNIFRAN-
Autor(es): dc.contributorUniversidade Federal de Sergipe (UFS)-
Autor(es): dc.creatorGasser, Beatriz [UNESP]-
Autor(es): dc.creatorRamirez Uscategui, Ricardo Andres-
Autor(es): dc.creatorMaronezi, Marjury Cristina [UNESP]-
Autor(es): dc.creatorPavan, Leticia [UNESP]-
Autor(es): dc.creatorRodrigues Simoes, Ana Paula [UNESP]-
Autor(es): dc.creatorMartinato, Fernanda [UNESP]-
Autor(es): dc.creatorSilva, Priscila [UNESP]-
Autor(es): dc.creatorCrivellenti, Leandro Zuccolotto-
Autor(es): dc.creatorRossi Feliciano, Marcus Antonio-
Data de aceite: dc.date.accessioned2022-02-22T00:06:18Z-
Data de disponibilização: dc.date.available2022-02-22T00:06:18Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-06-02-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-020-65902-4-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/195610-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/195610-
Descrição: dc.descriptionThe aetiology of septic acute kidney injury (AKI) is not completely elucidated. Early identification of AKI in septic patients is considered to improve survival rate since it allows rapid treatment onset. We evaluated clinical, haematological, urinary, B-mode, spectral Doppler, and contrast-enhanced ultrasound variables in 20 bitches with pyometra as sepsis models and 12 healthy controls. All animals with pyometra presented some degree of renal damage on histological examination; however, sequential organ failure assessment (SOFA) classified only 40% cases with sepsis. AKI derived from systemic infection was identified in 57% of cases with hypoperfusion and in 22% with inflammation, being an affection of multifactorial origin. Among the evaluated parameters, urinary protein/creatinine ratio >0.15, serum albumin <2.94mg/dL, time-averaged minimum velocity <21.5cm/s, renal length/aorta diameter ratio >5.93, pulsatility index >1.53, haematocrit <45%, time-averaged maximum velocity <45.7cm/s, haemoglobin <16g/dL, leukocytes >12.53 x 10(3)/uL, and cortical contrast peak intensity <69%, in the order of accuracy, are significant indicators of septic AKI with an accuracy >80%. Thus, AKI is a very prevalent condition in septic patients, derived mainly from changes in renal perfusion and inflammation. Additionally, reviewing the SOFA score parameters is suggested to identify renal failure.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSao Paulo State Univ Julio de Mesquita Filho, Sch Agr Sci & Vet Med, Jaboticabal, SP, Brazil-
Descrição: dc.descriptionFed Univ Jequitinhonha & Mucuri Valleys UFVJM, Inst Agr Sci, Unai, MG, Brazil-
Descrição: dc.descriptionUniv Franca UNIFRAN, Franca, SP, Brazil-
Descrição: dc.descriptionUniv Fed Santa Maria, Santa Maria, RS, Brazil-
Descrição: dc.descriptionSao Paulo State Univ Julio de Mesquita Filho, Sch Agr Sci & Vet Med, Jaboticabal, SP, Brazil-
Descrição: dc.descriptionCNPq: 424885/2018-2-
Descrição: dc.descriptionCNPq: 309199/2017-4-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format12-
Idioma: dc.languageen-
Publicador: dc.publisherNature Publishing Group-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceWeb of Science-
Título: dc.titleClinical and ultrasound variables for early diagnosis of septic acute kidney injury in bitches with pyometra-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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