Low-cost hybrid scaffolds based on polyurethane and gelatin

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorNortheastern Univ-
Autor(es): dc.creatorRodrigues, Isabella Caroline Pereira-
Autor(es): dc.creatorWoigt, Luiza Freire-
Autor(es): dc.creatorPereira, Karina Danielle [UNESP]-
Autor(es): dc.creatorLuchessi, Augusto Ducati [UNESP]-
Autor(es): dc.creatorLopes, Eder Socrates Najar-
Autor(es): dc.creatorWebster, Thomas J.-
Autor(es): dc.creatorGabriel, Lais Pellizzer-
Data de aceite: dc.date.accessioned2022-02-22T00:06:18Z-
Data de disponibilização: dc.date.available2022-02-22T00:06:18Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jmrt.2020.04.049-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/195605-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/195605-
Descrição: dc.descriptionThe production of scaffolds using a combination of synthetic and natural polymers has been widely studied for numerous tissue engineering applications, as it results in a material with superior properties, combining availability, processability, and the strength and resilience of synthetic polymers with the high biocompatibility of natural polymers. In the present study, fibrous membranes composed of polyurethane and gelatin were fabricated by rotary jet spinning and were posteriorly characterized for their morphological, chemical composition, thermal stability, hydrophilic properties as well as cell viability. Viscosity measurements were taken to achieve the critical concentration of the polymeric solution (9% wt/v), and the production of fibers at different rotational speeds (3000, 6000, 9000 and 12,000 rpm) was performed to evaluate the effect of rotational speed on fiber diameter and morphology, as observed in scanning electron microscopy analyses. Continuous and bead-free fibers were achieved at 6000 rpm with average diameter of 12.5 mu m. Chemical composition characterization showed the characteristic peaks of both polymers and the absence of the organic solvent, while the addition of gelatin did not affect the thermal stability of the membrane (up to 314 degrees C). Additionally, the water contact angle proved the membrane hydrophilic nature (81.3 degrees). Cell viability assays exhibited cytocompatibility with endothelial cells for 24, 48 and 72 h. The results demonstrate that the PU-Gel combination with the rotary jet spinning process is promising to obtain low-cost scaffolds with interesting properties for numerous tissue engineering applications, and, thus, should be further studied. (C) 2020 Published by Elsevier B.V.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniv Estadual Campinas, Sch Appl Sci, Limeira, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Inst Biosci, Rio Claro, Brazil-
Descrição: dc.descriptionUniv Estadual Campinas, Sch Mech Engn, Campinas, Brazil-
Descrição: dc.descriptionNortheastern Univ, Dept Chem Engn, Boston, MA 02115 USA-
Descrição: dc.descriptionSao Paulo State Univ, Inst Biosci, Rio Claro, Brazil-
Descrição: dc.descriptionFAPESP: 2017/13273-6-
Descrição: dc.descriptionFAPESP: 2014/06111-1-
Formato: dc.format7777-7785-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationJournal Of Materials Research And Technology-jmr&t-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectImplant-
Palavras-chave: dc.subjectMembrane-
Palavras-chave: dc.subjectPolymer-
Palavras-chave: dc.subjectTissue engineering-
Palavras-chave: dc.subjectProtein-
Palavras-chave: dc.subjectRotary jet spinning-
Título: dc.titleLow-cost hybrid scaffolds based on polyurethane and gelatin-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.