Heterobimetallic Ru(ii)/Fe(ii) complexes as potent anticancer agents against breast cancer cells, inducing apoptosis through multiple targets

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Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorFed Inst Educ Sci & Technol Goias-
Autor(es): dc.contributorPontifical Catholic Univ Goias-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorMundim Guedes, Adriana Pereira-
Autor(es): dc.creatorMello-Andrade, Francyelli-
Autor(es): dc.creatorPires, Wanessa Carvalho-
Autor(es): dc.creatorMontes de Sousa, Maria Alice-
Autor(es): dc.creatorFaustino da Silva, Paula Francinete-
Autor(es): dc.creatorCamargo, Mariana S. de-
Autor(es): dc.creatorGemeiner, Hendryk [UNESP]-
Autor(es): dc.creatorAmauri, Menegario A. [UNESP]-
Autor(es): dc.creatorCardoso, Clever Gomes-
Autor(es): dc.creatorMelo Reis, Paulo Roberto de-
Autor(es): dc.creatorSilveira-Lacerda, Elisangela de Paula-
Autor(es): dc.creatorBatista, Alzir A.-
Data de aceite: dc.date.accessioned2022-02-22T00:06:00Z-
Data de disponibilização: dc.date.available2022-02-22T00:06:00Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1039/c9mt00272c-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/195507-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/195507-
Descrição: dc.descriptionAntimetastatic activity, high selectivity and cytotoxicity for human tumor cell lines make ruthenium(ii) complexes attractive for the development of new chemotherapeutic agents for cancer treatment. In this study, cytotoxic activities and the possible mechanism of cell death induced by three ruthenium complexes were evaluated, [Ru(MIm)(bipy)(dppf)]PF6(1), [RuCl(Im)(bipy)(dppf)]PF6(2) and [Ru(tzdt)(bipy)(dppf)]PF6(3). The results showed high cytotoxicity and selectivity indexes for the human triple-negative breast tumor cell line (MDA-MB-231) with IC(50)value and selectivity index for complex1(IC50= 0.33 +/- 0.03 mu M, SI = 4.48), complex2(IC50= 0.80 +/- 0.06 mu M, SI = 2.31) and complex3(IC50= 0.48 +/- 0.02 mu M, SI = 3.87). The mechanism of cell death induced in MDA-MB-231 cells, after treatment with complexes1-3, indicated apoptosis of the cells as a consequence of the increase in the percentage of cells in the Sub-G1 phase in the cell cycle analysis, characteristic morphological changes and the presence of apoptotic cells labeled with Annexin-V. Multiple targets of action were identified for complexes1and3with an induction of DNA damage in cells treated with complexes1and3, mitochondrial depolarization with a reduction in mitochondrial membrane potential, an increase in reactive oxygen species levels and increased expression levels of caspase 3 and p53. In addition, antimetastatic activities for complexes1and3were observed by inhibition of cell migration by the wound healing assay and Boyden chamber assay, as well as inhibition of angiogenesis caused by MDA-MB-231 tumor cells in the CAM model.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniv Fed Sao Carlos, Dept Chem, CP 676, BR-13565905 Sao Carlos, SP, Brazil-
Descrição: dc.descriptionUniv Fed Goias, Inst Biol Sci, Dept Genet, BR-74690900 Goiania, Go, Brazil-
Descrição: dc.descriptionFed Inst Educ Sci & Technol Goias, Dept Chem, BR-74055110 Goiania, Go, Brazil-
Descrição: dc.descriptionPontifical Catholic Univ Goias, Lab Expt & Biotechnol Res, Masters Program Environm Sci & Hlth, Sch Med Sci,Pharmaceut & Biomed Lab, BR-74605010 Goiania, Go, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Ctr Environm Studies, BR-13506900 Rio Claro, SP, Brazil-
Descrição: dc.descriptionUniv Fed Goias, Inst Biol Sci, Dept Morphol, BR-74690900 Goiania, Go, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Ctr Environm Studies, BR-13506900 Rio Claro, SP, Brazil-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2016/16312-0-
Formato: dc.format547-561-
Idioma: dc.languageen-
Publicador: dc.publisherRoyal Soc Chemistry-
Relação: dc.relationMetallomics-
???dc.source???: dc.sourceWeb of Science-
Título: dc.titleHeterobimetallic Ru(ii)/Fe(ii) complexes as potent anticancer agents against breast cancer cells, inducing apoptosis through multiple targets-
Tipo de arquivo: dc.typelivro digital-
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