Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de Brasília (UnB)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorAndrade, Laise R. de-
Autor(es): dc.creatorTedesco, Antonio C.-
Autor(es): dc.creatorPrimo, Fernando L. [UNESP]-
Autor(es): dc.creatorFarias, Gabriel R.-
Autor(es): dc.creatorSilva, Jaqueline R. da-
Autor(es): dc.creatorLongo, Joao P. F.-
Autor(es): dc.creatorAlmeida, Marcos C. de-
Autor(es): dc.creatorSouza, Paulo E. N. de-
Autor(es): dc.creatorAzevedo, Ricardo B. de-
Autor(es): dc.creatorPinheiro, Willie O.-
Autor(es): dc.creatorLacava, Zulmira G. M.-
Data de aceite: dc.date.accessioned2022-02-22T00:05:47Z-
Data de disponibilização: dc.date.available2022-02-22T00:05:47Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2217/nnm-2019-0458-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/195430-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/195430-
Descrição: dc.descriptionAim: Nano-5-aminolevulic acid (NanoALA)-mediated photodynamic therapy (PDT), an oil-in-water polymeric nanoemulsion of ALA, was evaluated in a murine model of breast cancer. Materials & methods: Analysis of ALA-derived protoporphyrin IX production and acute toxicity test, biocompatibility and treatment efficacy, and long-term effect of NanoALA-PDT on tumor progression were performed. Results: The nanoformulation favored the prodrug uptake by tumor cells in a shorter time (1.5 h). As a result, the adverse effects were negligible and the response rates for primary mammary tumor control were significantly improved. Tumor progression was slower after NanoALA-PDT treatment, providing longer survival. Conclusion: NanoALA is a good proactive drug candidate for PDT against cancer potentially applied as adjuvant/neoadjuvant intervention strategy for breast cancer.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFoundation to Support Research in the Federal District (FAPDF)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionNational Institute of Science and Technology in Nanobiotechnology (INCTNanobiotecnologia)-
Descrição: dc.descriptionCenter for Nanoscience and Nanobiotechnology of the University of Bras'ilia (CNANO-UnB)-
Descrição: dc.descriptionDean of Research and Post-Graduation of the University of Brasilia (DPP-UnB)-
Descrição: dc.descriptionUniv Brasilia, Inst Biol Sci, Dept Genet & Morphol, BR-70910900 Brasilia, DF, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto, Ctr Nanotechnol & Tissue Engn Photobiol, Dept Chem, BR-14010100 Ribeirao Preto, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto, Photomed Res Grp, BR-14010100 Ribeirao Preto, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Sch Pharmaceut Sci, Dept Engn Bioproc & Biotechnol, BR-14800903 Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Brasilia, Inst Phys, Lab Electron Paramagnet Resonance, BR-70919970 Brasilia, DF, Brazil-
Descrição: dc.descriptionUniv Brasilia, Fac Ceilandia, Postgrad Program Sci & Technol Hlth, BR-72220275 Brasilia, DF, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Sch Pharmaceut Sci, Dept Engn Bioproc & Biotechnol, BR-14800903 Araraquara, SP, Brazil-
Descrição: dc.descriptionFAPESP: 2013/50181-1-
Formato: dc.format1019-1036-
Idioma: dc.languageen-
Publicador: dc.publisherFuture Medicine Ltd-
Relação: dc.relationNanomedicine-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subject4T1 cells-
Palavras-chave: dc.subject5-aminolevulinic acid-
Palavras-chave: dc.subjectbreast cancer-
Palavras-chave: dc.subjectphotodynamic therapy-
Palavras-chave: dc.subjectpolymeric nanoemulsion-
Título: dc.titleTumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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