Sparger design as key parameter to define shear conditions in pneumatic bioreactors

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Autor(es): dc.contributorFed Inst Educ Sci & Technol Sao Paulo-
Autor(es): dc.contributorFed Univ Rio Grande-
Autor(es): dc.contributorUniv Fed Itajuba-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.creatorEsperanca, Mateus N.-
Autor(es): dc.creatorMendes, Caroline E.-
Autor(es): dc.creatorRodriguez, Guilherme Y.-
Autor(es): dc.creatorCerri, Marcel O. [UNESP]-
Autor(es): dc.creatorBettega, Rodrigo-
Autor(es): dc.creatorBadino, Alberto C.-
Data de aceite: dc.date.accessioned2022-02-22T00:05:30Z-
Data de disponibilização: dc.date.available2022-02-22T00:05:30Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-04-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bej.2020.107529-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/195324-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/195324-
Descrição: dc.descriptionThe average shear rate (<(gamma)over dot>(av)) is a parameter used to characterize the shear environment in bioreactors, enabling comparison of the performances of different bioreactor models in terms of microorganism morphology and viability, and consequently bioproduct formation. Based on this approach, pneumatic bioreactors have been classified as low shear devices. However, the shear behavior cannot be generalized over a wide range of operating conditions, suggesting that the maximum shear rate (<(gamma)over dot>(max)) may be more suitable for the purpose of bioreactor performance comparison. Therefore, the aim of this work was to evaluate average and maximum shear rates in pneumatic bioreactors (bubble column and airlift), based on computational fluid dynamics (CFD) simulations. Concentric-duct and split airlift bioreactors exhibited higher <(gamma)over dot>(av) values, compared to the bubble column design, due to the nature of the liquid circulation patterns. The pneumatic bioreactors exhibited a significant (order of magnitude) difference between <(gamma)over dot>(av) (11.0-27.3 s(-1)) and <(gamma)over dot>(max) 4555 to 25,040 s(-1)), reflecting a non-uniform spatial distribution. The <(gamma)over dot>(max) values occurred close to the sparger holes and presented a linear relationship with gas injection velocity, which is dependent on the sparger geometry. In this way, sparger characteristics (number and diameter of sparger holes) defined <(gamma)over dot>(max) values in pneumatic bioreactors, showing that sparger should be properly designed in order to avoid excessive local shear rates.-
Descrição: dc.descriptionHuman Resources Program of the Brazilian National Agency of Petroleum, Natural Gas, and Biofuels-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFed Inst Educ Sci & Technol Sao Paulo, Campus Capivari, BR-13360000 Capivari, SP, Brazil-
Descrição: dc.descriptionFed Univ Rio Grande, Chem & Food Sch, Carreiros, RS, Brazil-
Descrição: dc.descriptionUniv Fed Itajuba, Nat Resources Inst, Bioproc Engn Course, Itajuba, MG, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Fac Pharmaceut Sci, Dept Bioproc & Biotechnol, Araraquara, SP, Brazil-
Descrição: dc.descriptionUniv Fed Sao Carlos, Grad Program Chem Engn, CP 676, BR-13565905 Sao Carlos, SP, Brazil-
Descrição: dc.descriptionSao Paulo State Univ, Fac Pharmaceut Sci, Dept Bioproc & Biotechnol, Araraquara, SP, Brazil-
Descrição: dc.descriptionHuman Resources Program of the Brazilian National Agency of Petroleum, Natural Gas, and Biofuels: PRH/ANP-44-
Descrição: dc.descriptionCNPq: 478472/2011-0-
Descrição: dc.descriptionFAPESP: 2011/23807-1-
Descrição: dc.descriptionFAPESP: 2012/17756-8-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format12-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationBiochemical Engineering Journal-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectPneumatic bioreactor-
Palavras-chave: dc.subjectComputational fluid dynamics-
Palavras-chave: dc.subjectShear rate-
Palavras-chave: dc.subjectSparger design-
Título: dc.titleSparger design as key parameter to define shear conditions in pneumatic bioreactors-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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