Advances in dual functional antimicrobial and osteoinductive biomaterials for orthopaedic applications

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorHarvard Med Sch-
Autor(es): dc.contributorMIT-
Autor(es): dc.contributorNortheastern Univ-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUppsala Univ-
Autor(es): dc.contributorUFPI Fed Univ Piaui-
Autor(es): dc.creatorAfewerki, Samson-
Autor(es): dc.creatorBassous, Nicole-
Autor(es): dc.creatorHarb, Samarah [UNESP]-
Autor(es): dc.creatorPalo-Nieto, Carlos-
Autor(es): dc.creatorRuiz-Esparza, Guillermo U.-
Autor(es): dc.creatorMarciano, Fernanda R.-
Autor(es): dc.creatorWebster, Thomas J.-
Autor(es): dc.creatorAguiar Furtado, Andre Sales-
Autor(es): dc.creatorLobo, Anderson O.-
Data de aceite: dc.date.accessioned2022-02-22T00:05:22Z-
Data de disponibilização: dc.date.available2022-02-22T00:05:22Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.nano.2019.102143-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/195272-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/195272-
Descrição: dc.descriptionA vast growing problem in orthopaedic medicine is the increase of clinical cases with antibiotic resistant pathogenic microbes, which is predicted to cause higher mortality than all cancers combined by 2050. Bone infectious diseases limit the healing ability of tissues and increase the risk of future injuries due to pathologic tissue remodelling. The traditional treatment for bone infections has several drawbacks and limitations, such as lengthy antibiotic treatment, extensive surgical interventions, and removal of orthopaedic implants and/or prosthesis, all of these resulting in long-term rehabilitation. This is a huge burden to the public health system resulting in increased healthcare costs. Current technologies e.g. co-delivery systems, where antibacterial and osteoinductive agents are delivered encounter challenges such as site-specific delivery, sustained and prolonged release, and biocompatibility. In this review, these aspects are highlighted to promote the invention of the next generation biomaterials to prevent and/or treat bone infections and promote tissue regeneration. (C) 2019 Elsevier Inc. All rights reserved.-
Descrição: dc.descriptionSweden-America Foundation (The Family Mix Entrepreneur Foundation)-
Descrição: dc.descriptionOlle Engkvist Byggmastare Foundation-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionHarvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Cambridge, MA 02139 USA-
Descrição: dc.descriptionMIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA-
Descrição: dc.descriptionNortheastern Univ, Dept Chem Engn, Nanomed Lab, Boston, MA 02115 USA-
Descrição: dc.descriptionSao Paulo State Univ, Inst Chem, Araraquara, SP, Brazil-
Descrição: dc.descriptionUppsala Univ, BMC, Dept Med Chem, Uppsala, Sweden-
Descrição: dc.descriptionUFPI Fed Univ Piaui, Dept Phys, Teresina, PI, Brazil-
Descrição: dc.descriptionUFPI Fed Univ Piaui, Dept Mat Engn, LIMAV Interdisciplinary Lab Adv Mat, BR-64049550 Teresina, PI, Brazil-
Descrição: dc.descriptionMIT, Dept Chem, Cambridge, MA 02139 USA-
Descrição: dc.descriptionSao Paulo State Univ, Inst Chem, Araraquara, SP, Brazil-
Descrição: dc.descriptionCNPq: 303752/2017-3-
Descrição: dc.descriptionCNPq: 404683/2018-5-
Descrição: dc.descriptionCNPq: 304133/2017-5-
Formato: dc.format29-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationNanomedicine-nanotechnology Biology And Medicine-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectAntibacterial-
Palavras-chave: dc.subjectOsteoinduction-
Palavras-chave: dc.subjectBiomaterials-
Palavras-chave: dc.subjectOrthopedic-
Palavras-chave: dc.subjectTissue engineering-
Título: dc.titleAdvances in dual functional antimicrobial and osteoinductive biomaterials for orthopaedic applications-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.