Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | CSIC | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (Unesp) | - |
Autor(es): dc.contributor | Univ Barcelona | - |
Autor(es): dc.contributor | Russian Acad Sci | - |
Autor(es): dc.contributor | Tomsk State Univ | - |
Autor(es): dc.contributor | Inst Res & Technol Food & Agr IRTA | - |
Autor(es): dc.contributor | Univ Valencia | - |
Autor(es): dc.creator | Dallares, Sara | - |
Autor(es): dc.creator | Dourado, Priscila [UNESP] | - |
Autor(es): dc.creator | Sanahuja, Ignasi | - |
Autor(es): dc.creator | Solovyev, Mikhail | - |
Autor(es): dc.creator | Gisbert, Enric | - |
Autor(es): dc.creator | Montemurro, Nicola | - |
Autor(es): dc.creator | Torreblanca, Amparo | - |
Autor(es): dc.creator | Blazquez, Mercedes | - |
Autor(es): dc.creator | Sole, Montserrat | - |
Data de aceite: dc.date.accessioned | 2022-02-22T00:04:58Z | - |
Data de disponibilização: dc.date.available | 2022-02-22T00:04:58Z | - |
Data de envio: dc.date.issued | 2020-12-09 | - |
Data de envio: dc.date.issued | 2020-12-09 | - |
Data de envio: dc.date.issued | 2020-01-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1016/j.aquatox.2019.105378 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/195165 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/195165 | - |
Descrição: dc.description | Fipronil is a phenylpyrazole insecticide widely used to control pests in agriculture even though evidence of harmful side effects in non-target species has been reported. A comprehensive study on the effects of dietary administration of Regent (R) 800WG (80 % fipronil) in European sea bass juveniles was carried out under two temperature regimes: a) natural conditions, and b) 3 degrees C above the natural temperature (an increase predicted for the NW Mediterranean by the end of this century). Fipronil was added to the fish food (10 mg fipronil /Kg feed) and the effects were studied at several time points including right before administration, 7 and 14 days after daily fipronil feed and one-week after the insecticide withdrawal from the diet (depuration period). A wide array of physiological and metabolic biomarkers including feeding rate, general condition indices, plasma and epidermal mucus metabolites, immune response, osmoregulation, detoxification and oxidative-stress markers and digestive enzymes were assessed. General linear models and principal component analyses indicated that regardless of water temperature, fipronil resulted in a significant alteration of several of the above listed biomarkers. Among them, glucose and lactate levels increased in plasma and decreased in epidermal mucus as indicators of a stress response. Similarly, a depletion in catalase activity and higher lipid peroxidation in liver of fipronil-exposed fish were also indicative of an oxidative-stress condition. Fipronil induced a time dependent inhibition of Cytochrome P450-related activities and an increase of phase II glutathione-S-transferase. Moreover, fipronil administration was able to reduce the hypo-osmoregulatory capability as shown by the increase of plasmatic osmolality and altered several digestive enzymes including trypsin, lipase, alpha amylase and maltase. Finally, analyses in bile and muscle confirmed the rapid clearance of fipronil but the persistence of the metabolite fipronil-sulfone in bile even after the 7-day depuration period. Altogether, the results reveal a notable impact of this compound on the physiological condition of the European sea bass. The results should be considered in future environmental risk assessment studies since fipronil could be hazardous to fish species, particularly those inhabiting estuarine ecosystems exposed to the discharge of agriculture runoffs where this pesticide is mainly used. | - |
Descrição: dc.description | Spanish Ministry of Economy, Industry and Competivity | - |
Descrição: dc.description | Catalonian Government (Excellence Research Groups) | - |
Descrição: dc.description | Spanish Ministry of Science Innovation and Universities | - |
Descrição: dc.description | CSIC, Inst Marine Sci, ICM, Pg Maritim Barceloneta 37-49, Barcelona 08003, Spain | - |
Descrição: dc.description | Paulist State Univ Julio de Mesquita Filho, Inst Biosci Language & Exact Sci Sao Jose do Rio, Rua Cristovao Colombo 1897-1898 Ao Fim, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil | - |
Descrição: dc.description | Univ Barcelona, Fac Biol, Dept Cell Biol Physiol & Immunol, Avda Diagonal 643, E-08028 Barcelona, Spain | - |
Descrição: dc.description | Russian Acad Sci, Inst Systemat & Ecol Anim, Siberian Branch, Frunze St 11, Novosibirsk 630091, Russia | - |
Descrição: dc.description | Tomsk State Univ, 36 Lenin Ave, Tomsk 634050, Russia | - |
Descrição: dc.description | Inst Res & Technol Food & Agr IRTA, Aquaculture Program, Ctra Poble Nou,Km 5-5, Tarragona 43540, Spain | - |
Descrição: dc.description | CSIC, Water & Soil Qual Res Grp, IDAEA, Dept Environm Chem, C Jordi Girona 18-26, Barcelona 08034, Spain | - |
Descrição: dc.description | Univ Valencia, Dept Funct Biol & Phys Anthropol, C Dr Moliner 50, Valencia 46100, Spain | - |
Descrição: dc.description | Paulist State Univ Julio de Mesquita Filho, Inst Biosci Language & Exact Sci Sao Jose do Rio, Rua Cristovao Colombo 1897-1898 Ao Fim, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil | - |
Descrição: dc.description | Spanish Ministry of Economy, Industry and Competivity: CGL2016-76332-R | - |
Descrição: dc.description | Catalonian Government (Excellence Research Groups): 2017SGR00902 | - |
Descrição: dc.description | Spanish Ministry of Science Innovation and Universities: RTI2018-094667-B-C21 | - |
Descrição: dc.description | : FAPESP2017/18210-2 | - |
Formato: dc.format | 12 | - |
Idioma: dc.language | en | - |
Publicador: dc.publisher | Elsevier B.V. | - |
Relação: dc.relation | Aquatic Toxicology | - |
???dc.source???: dc.source | Web of Science | - |
Palavras-chave: dc.subject | Fipronil | - |
Palavras-chave: dc.subject | Sea bass | - |
Palavras-chave: dc.subject | Biomarkers | - |
Palavras-chave: dc.subject | CYP metabolism | - |
Palavras-chave: dc.subject | Oxidative stress | - |
Palavras-chave: dc.subject | Climate change | - |
Título: dc.title | Multibiomarker approach to fipronil exposure in the fish Dicentrarchus labrax under two temperature regimes | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: