Evaluation of toceranib for treatment of apocrine gland anal sac adenocarcinoma in dogs

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniv Wisconsin-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorHeaton, Caitlin M.-
Autor(es): dc.creatorFernandes, Arthur F. A.-
Autor(es): dc.creatorJark, Paulo C. [UNESP]-
Autor(es): dc.creatorPan, Xuan-
Data de aceite: dc.date.accessioned2022-02-22T00:04:57Z-
Data de disponibilização: dc.date.available2022-02-22T00:04:57Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-01-23-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/jvim.15706-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/195160-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/195160-
Descrição: dc.descriptionBackground There is no widely accepted standard medical treatment for apocrine gland anal sac adenocarcinoma (AGASACA) in dogs. Targeted agents such as toceranib may be effective in treatment of AGASACA, but the number of clinical reports investigating its efficacy is limited. Hypothesis/Aim To evaluate the efficacy of toceranib treatment of AGASACA in dogs, and to assess prognostic factors in the study population. Our hypothesis was that toceranib would provide a clinical benefit in the treatment of dogs with AGASACA. Animals Thirty-six client-owned dogs with either a cytologic or histologic diagnosis of AGASACA that were treated with toceranib alone or in combination with surgery, nonconcurrent chemotherapy or both. Methods Retrospective study. Result The median progression-free survival (PFS) and overall survival time (OST) for the study population was 313 days and 827 days, respectively. A clinical benefit from toceranib treatment was observed in 69% of dogs, with 20.7% of dogs experiencing partial response and 48.3% of dogs experiencing stable disease. Dogs that responded to toceranib treatment had significantly prolonged PFS and OST. Hypercalcemia was a negative prognostic factor for clinical outcomes. Conclusions Toceranib is effective in the treatment of AGASACA in dogs. Prospective, controlled clinical trials are needed to determine the efficacy of toceranib in comparison to other treatment protocols for dogs with AGASACA.-
Descrição: dc.descriptionNational Institutes of Health-
Descrição: dc.descriptionUniversity of Wisconsin-Madison-
Descrição: dc.descriptionUniv Wisconsin, Sch Vet Med, Dept Med Sci, 2015 Linden Dr, Madison, WI 53706 USA-
Descrição: dc.descriptionUniv Wisconsin, Anim Sci, Madison, WI 53706 USA-
Descrição: dc.descriptionUniv Estadual Paulista, Campus Jaboticabal, Jaboticabal, SP, Brazil-
Descrição: dc.descriptionUniv Wisconsin, Carbone Canc Ctr, Madison, WI 53706 USA-
Descrição: dc.descriptionUniv Estadual Paulista, Campus Jaboticabal, Jaboticabal, SP, Brazil-
Descrição: dc.descriptionNational Institutes of Health: K01OD020153-01A1-
Formato: dc.format873-881-
Idioma: dc.languageen-
Publicador: dc.publisherWiley-Blackwell-
Relação: dc.relationJournal Of Veterinary Internal Medicine-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectAGASACA-
Palavras-chave: dc.subjectcanine-
Palavras-chave: dc.subjectOST-
Palavras-chave: dc.subjectPFS-
Título: dc.titleEvaluation of toceranib for treatment of apocrine gland anal sac adenocarcinoma in dogs-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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