In vitro cytotoxic effects of Brazilian plant extracts on squamous cell carcinoma of the oral cavity

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorOzi, Joana Mattos [UNESP]-
Autor(es): dc.creatorSuffredini, Ivana Barbosa [UNESP]-
Autor(es): dc.creatorPaciencia, Mateus [UNESP]-
Autor(es): dc.creatorFrana, Sergio Alexandre [UNESP]-
Autor(es): dc.creatorDib, Luciano Lauria [UNESP]-
Data de aceite: dc.date.accessioned2022-02-22T00:03:45Z-
Data de disponibilização: dc.date.available2022-02-22T00:03:45Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2011-11-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/S1806-83242011000600008-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/194752-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/194752-
Descrição: dc.descriptionSquamous cell carcinoma (SCC) is the most prevalent cancer of the oral cavity and the fifth most prevalent of all malignancies in males. Many researchers have attempted to develop new treatments that will improve the prognosis of SCC patients. Over 20% of the world's biodiversity is located within the Brazilian forests, but little is known about the chemical and/or pharmacological potential of these plants. Certain extracts obtained from Amazon and Atlantic Forest plants have previously been shown to have cytotoxic activity against various cancers. The aim of this study was to screen these extracts for cytotoxic activity against oral SCC cells. The extracts were analyzed for activity against the KB-ADL#12 cell line at various concentrations up to a maximum dose of 100 mu g/mL. Comparisons with a control group were performed using one-way ANOVA. Significant cytotoxicity was induced by the extracts obtained from the aerial parts of Picrolemma sprucei (Simaroubaceae), from the leaves and stems of Laetia suaveolens (Salicaceae), from the aerial parts of Abarema auriculata (Fabaceae-Mimosoideae) and from the stem of A. auriculata.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionUniv Estadual Paulista, Grad Program Dent, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Ctr Res Biodivers, Extract Lab, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, UNIP Herbarium, Ctr Res Biodivers, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Grad Program Dent, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, Ctr Res Biodivers, Extract Lab, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Estadual Paulista, UNIP Herbarium, Ctr Res Biodivers, Sao Paulo, Brazil-
Descrição: dc.descriptionFAPESP: 08/58706-8-
Formato: dc.format519-525-
Idioma: dc.languageen-
Publicador: dc.publisherSociedade Brasileira De Pesquisa Odontologica-
Relação: dc.relationBrazilian Oral Research-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectMouth Neoplasm-
Palavras-chave: dc.subjectCarcinoma-
Palavras-chave: dc.subjectSquamous Cell-
Palavras-chave: dc.subjectPlant Extracts-
Título: dc.titleIn vitro cytotoxic effects of Brazilian plant extracts on squamous cell carcinoma of the oral cavity-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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