Lymphangiogenic VEGF-C and VEGFR-3 expression in genetically characterised gastrointestinal stromal tumours

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorBarretos Canc Hosp-
Autor(es): dc.contributorUniv Minho-
Autor(es): dc.contributorAlto Ave Super Inst Hlth ISAVE-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.creatorTorres de Oliveira, Antonio Talvane-
Autor(es): dc.creatorReis, Rui M.-
Autor(es): dc.creatorAfonso, Julieta-
Autor(es): dc.creatorMartinho, Olga-
Autor(es): dc.creatorMatos, Delcio-
Autor(es): dc.creatorCarvalho, Andre Lopes-
Autor(es): dc.creatorVazquez, Vinicius Lima-
Autor(es): dc.creatorSilva, Thiago Buosi-
Autor(es): dc.creatorScapulatempo, Cristovam-
Autor(es): dc.creatorSaad, Sarhan Sydney-
Autor(es): dc.creatorLongatto-Filho, Adhemar-
Data de aceite: dc.date.accessioned2022-02-22T00:03:41Z-
Data de disponibilização: dc.date.available2022-02-22T00:03:41Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2011-12-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/194730-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/194730-
Descrição: dc.descriptionThis study aimed to assess the distribution of VEGF-C and VEGFR-3 expression in gastrointestinal stromal tumours (GISTs), and to analyse the value of lymphatic vessel density (LVD) in a tumour that is believed to preferentially metastasize through blood vessel conduits. A panel of immunohistochemical antibodies was used to evaluate 51 cases of genetically characterised GISTs: VEGF-C, VEGFR-3, D2-40 (for LVD assessment) and CD31 (for blood vessel density BDV - assessment). The results were correlated with the clinical-pathological data. The large majority of cases (86.2%; 44/51) showed a mutation of the KIT gene, most of them (72.5%; 37/51) revealing mutations in exon 11. VEGFR-3 was predominantly expressed in KIT mutated GISTs (p=0.019). High LVD was correlated with the absence of metastasis (p=0.010) and high BVD showed a positive correlation with the occurrence of metastasis (p=0.049). The strong expression of VEGF-C and VEGFR-3 in GIST's cells was not correlated with the clinical parameters of aggressiveness, nor with high LVD.-
Descrição: dc.descriptionPortuguese Science and Technology Foundation-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionBarretos Canc Hosp, Pio XII Fdn, Dept Digest Surg, Sao Paulo, Brazil-
Descrição: dc.descriptionBarretos Canc Hosp, Pio XII Fdn, Dept Pathol, Sao Paulo, Brazil-
Descrição: dc.descriptionBarretos Canc Hosp, Pio XII Fdn, Ctr Researcher Support, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Braga, Portugal-
Descrição: dc.descriptionBarretos Canc Hosp, Pio XII Fdn, Mol Oncol Res Ctr, Sao Paulo, Brazil-
Descrição: dc.descriptionAlto Ave Super Inst Hlth ISAVE, Povoa De Lanhoso, Portugal-
Descrição: dc.descriptionFed Univ Sao Paulo UNIFESP, Sch Med, Dept Gastroenterol, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Sao Paulo, Sch Med, Lab Med Invest LIM 14, Dept Pathol, BR-05508 Sao Paulo, Brazil-
Descrição: dc.descriptionPortuguese Science and Technology Foundation: SFRH/BD/36463/2007-
Descrição: dc.descriptionCNPq: 476936/2008-0-
Formato: dc.format1499-1507-
Idioma: dc.languageen-
Publicador: dc.publisherF Hernandez-
Relação: dc.relationHistology And Histopathology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjectGastrointestinal stromal tumours-
Palavras-chave: dc.subjectKIT-
Palavras-chave: dc.subjectD2-40-
Palavras-chave: dc.subjectVEGF-C-
Palavras-chave: dc.subjectVEGFR-3-
Título: dc.titleLymphangiogenic VEGF-C and VEGFR-3 expression in genetically characterised gastrointestinal stromal tumours-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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