Adjuvant effect of LPS and killed Propionibacterium acnes on the development of experimental gastrointestinal nematode infestation in sheep

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Autor(es): dc.contributorUniversidade Estadual Paulista (Unesp)-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorAgRes Grasslands Res Ctr-
Autor(es): dc.creatorAbel, L. C. J. [UNESP]-
Autor(es): dc.creatorChen, S. [UNESP]-
Autor(es): dc.creatorRicca, L. G. [UNESP]-
Autor(es): dc.creatorMartins, M. F. [UNESP]-
Autor(es): dc.creatorGarcia, M. [UNESP]-
Autor(es): dc.creatorAnanias, R. Z.-
Autor(es): dc.creatorMussalem, J. S.-
Autor(es): dc.creatorSquaiella, C. C.-
Autor(es): dc.creatorShaw, R. J.-
Autor(es): dc.creatorLongo-Maugeri, I. M.-
Data de aceite: dc.date.accessioned2022-02-22T00:03:38Z-
Data de disponibilização: dc.date.available2022-02-22T00:03:38Z-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2020-12-09-
Data de envio: dc.date.issued2009-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/j.1365-3024.2009.01132.x-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/194708-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/194708-
Descrição: dc.descriptionP>Gastrointestinal helminthic infection is an important worldwide sheep disease. The emergence of anthelminthic resistance has led to drives to seek new means of therapeutic control of helminthiasis in sheep. Several data demonstrated the adjuvant effect of Propionibacterium acnes on resistance to infection. Herein, we evaluate the adjuvant effect of the commercial suspension containing LPS and P. acnes on experimental helminthiasis. Sheep received three doses of LPS and P. acnes commercial suspension or saline 0 center dot 9% (control group). Both groups received orally Haemonchus contortus infective larvae on day 0. Parasitological, haematological, lymphoproliferation analysis, IL-5 and IgE determination were made once a week until 35th day after infection. Our results revealed increase on packed cell volumes on day 14, in LPS + P. acnes treated group. On 21st and 35th days after infection in the same group occurred increase on circulating eosinophils and lymphocytes, and also in the lymphoproliferative response to mitogen. On 35th day, the faecal eggs peak in LPS + P. acnes treated group was significantly lower than control. A negative correlation between faecal eggs counts and circulating eosinophils in the immunostimulant treated group was also observed. Our findings suggest that LPS + P. acnes suspension can be used as a strategy to control helminthiasis in sheep.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionUniversidade Paulista (UNIP)-
Descrição: dc.descriptionUniv Estadual Paulista, UNIP, Sao Paulo, Brazil-
Descrição: dc.descriptionUniv Fed Sao Paulo, Div Immunol, UNIFESP, Sao Paulo, Brazil-
Descrição: dc.descriptionAgRes Grasslands Res Ctr, Hopkirk Res Inst, Palmerston North, New Zealand-
Descrição: dc.descriptionUniv Estadual Paulista, UNIP, Sao Paulo, Brazil-
Formato: dc.format604-612-
Idioma: dc.languageen-
Publicador: dc.publisherWiley-Blackwell-
Relação: dc.relationParasite Immunology-
???dc.source???: dc.sourceWeb of Science-
Palavras-chave: dc.subjecthelminthiasis-
Palavras-chave: dc.subjectimmunostimulant-
Palavras-chave: dc.subjectlymphocytes-
Palavras-chave: dc.subjectsheep-
Título: dc.titleAdjuvant effect of LPS and killed Propionibacterium acnes on the development of experimental gastrointestinal nematode infestation in sheep-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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