Crystallization and preliminary X-ray crystallographic analysis of chorismate synthase from Mycobacterium tuberculosis

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDias, MVB-
Autor(es): dc.creatorEly, F.-
Autor(es): dc.creatorCanduri, F.-
Autor(es): dc.creatorPereira, J. F.-
Autor(es): dc.creatorBasso, L. A.-
Autor(es): dc.creatorPalma, Mario Sergio-
Autor(es): dc.creatorde Azevedo, W. F.-
Autor(es): dc.creatorSantos, D. S.-
Data de aceite: dc.date.accessioned2021-03-10T17:14:07Z-
Data de disponibilização: dc.date.available2021-03-10T17:14:07Z-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2004-11-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1107/S0907444904019869-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/19411-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/19411-
Descrição: dc.descriptionThe enzymes of the shikimate pathway are potential targets for the development of new therapies because they are essential for bacteria but absent from mammals. The last step in this pathway is performed by chorismate synthase (CS), which catalyzes the conversion of 5-enolpyruvylshikimate-3-phosphate to chorismate. Optimization of crystallization trials allowed the crystallization of homogeneous recombinant CS from Mycobacterium tuberculosis (MtCS). The crystals of MtCS belong to space group P6(4)22 (or P6(2)22) and diffract to 2.8 Angstrom resolution, with unit-cell parameters a = b = 129.7, c = 156.8 Angstrom. There are two molecules in the asymmetric unit. Molecular-replacement trials were not sucessful. Heavy-atom derivative screening is in progress.-
Formato: dc.format2003-2005-
Idioma: dc.languageen-
Publicador: dc.publisherBlackwell Munksgaard-
Relação: dc.relationActa Crystallographica Section D: Biological Crystallography-
Direitos: dc.rightsclosedAccess-
Título: dc.titleCrystallization and preliminary X-ray crystallographic analysis of chorismate synthase from Mycobacterium tuberculosis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.