Cardiovascular and hidroelectrolytic changes in rats fed with high-fat diet

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSá, Jéssica Matheus-
Autor(es): dc.creatorBarbosa, Rafaela Moreira-
Autor(es): dc.creatorMenani, José V.-
Autor(es): dc.creatorDe Luca, Laurival Antônio-
Autor(es): dc.creatorColombari, Eduardo-
Autor(es): dc.creatorAlmeida Colombari, Débora Simões-
Data de aceite: dc.date.accessioned2021-03-11T01:41:56Z-
Data de disponibilização: dc.date.available2021-03-11T01:41:56Z-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-11-04-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2019.112075-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/190512-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/190512-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionProcesso FAPESP: 2015/234677-
Descrição: dc.descriptionProcesso FAPESP: 2017/10762-6-
Descrição: dc.descriptionCNPq: 308099/2017-6-
Descrição: dc.descriptionCNPq: 425586/2016-2-
Descrição: dc.descriptionObesity activates the renin-angiotensin and sympathetic systems facilitating hypertension and changes in the hydroelectrolytic balance. In the present study, in rats fed with high-fat diet (HFD), we investigated daily water intake and urinary excretion, prandial consumption of water and the changes in blood pressure and water intake to intracerebroventricular (icv) angiotensin II (ANG II). Male Holtzman rats (290–320 g) were fed with standard diet (SD, 11% calories from fat) or HFD (45% calories from fat) for 6 weeks. Part of the animals received a stainless steel cannula in the lateral ventricle (LV) at the 6th week after the beginning of the diets and the experiments were performed at the 7th week. The pressor effect, but not the dipsogenic response to acute icv injection of ANG II, was potentiated in the HFD rats. Daily water intake and urinary volume were reduced in rats fed with HFD with no significant changes in sodium excretion. Prandial water consumption was also reduced in rats ingesting HFD, an effect almost totally reverted blocking salivation with atropine. These results show a potentiation of the pressor response to icv ANG II in HFD-fed rats, without changing icv ANG II-induced water intake. In addition, prandial and daily water intake and urinary volume were reduced in HFD-fed rats, without changing sodium excretion. Salivation in rats ingesting HFD may play a role in the reduced prandial and daily water intake.-
Idioma: dc.languageen-
Relação: dc.relationBehavioural Brain Research-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectAngiotensin II-
Palavras-chave: dc.subjectArterial pressure-
Palavras-chave: dc.subjectObesity-
Palavras-chave: dc.subjectRenal excretion-
Palavras-chave: dc.subjectWater intake-
Título: dc.titleCardiovascular and hidroelectrolytic changes in rats fed with high-fat diet-
Tipo de arquivo: dc.typelivro digital-
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