Gene expression profiling and identification of hub genes in Nellore cattle with different marbling score levels

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorFonseca, Larissa Fernanda Simielli-
Autor(es): dc.creatordos Santos Silva, Danielly Beraldo-
Autor(es): dc.creatorGimenez, Daniele Fernanda Jovino-
Autor(es): dc.creatorBaldi, Fernando-
Autor(es): dc.creatorFerro, Jesus Aparecido-
Autor(es): dc.creatorChardulo, Luis Artur Loyola-
Autor(es): dc.creatorde Albuquerque, Lucia Galvão-
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Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionProcesso FAPESP: 2009/16118-5-
Descrição: dc.descriptionProcesso FAPESP: 2013/09190-7-
Descrição: dc.descriptionThe marbling rate evaluation is difficult and expensive, requiring slaughter of the animal or ultrasound measurement. Thus, this trait is generally not included in animal breeding programs. The use of molecular techniques to elucidate intramuscular fat deposition may help improve this trait. In this respect, transcriptome studies and differential gene expression analysis by RNA-Seq can contribute to advances in this area. The objective of this study was to use RNA-Seq to identify differentially expressed genes (DEGs) in muscle tissue (longissimus thoracis) of Nellore cattle divergently ranked on marbling, in order to increase our understanding of genes involved in the expression of this trait. The results revealed 49 DEGs and three hub genes (CISH, UFM1, TSHZ1), all of them involved in insulin and diabetes mellitus metabolism. These results indicating key genes and pathways, which may help to develop strategies designed to select animals with greater marbling.-
Idioma: dc.languageen-
Relação: dc.relationGenomics-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectIntramuscular fat-
Palavras-chave: dc.subjectMeat quality-
Palavras-chave: dc.subjectRNA-Seq-
Palavras-chave: dc.subjectTranscriptome-
Título: dc.titleGene expression profiling and identification of hub genes in Nellore cattle with different marbling score levels-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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