Novel polymeric dressing to the treatment of infected chronic wound

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorGarms, Bruna Cambraia-
Autor(es): dc.creatorBorges, Felipe Azevedo-
Autor(es): dc.creatorde Barros, Natan Roberto-
Autor(es): dc.creatorMarcelino, Mônica Yonashiro-
Autor(es): dc.creatorLeite, Marcel Nani-
Autor(es): dc.creatorDel Arco, Marina Constante-
Autor(es): dc.creatorde Souza Salvador, Sérgio Luiz-
Autor(es): dc.creatorPegorin, Giovana Sant’Ana-
Autor(es): dc.creatorOliveira, Kassandra Sussi Mustafé-
Autor(es): dc.creatorFrade, Marco Andrey Cipriani-
Autor(es): dc.creatorHerculano, Rondinelli Donizetti-
Data de aceite: dc.date.accessioned2021-03-11T01:41:24Z-
Data de disponibilização: dc.date.available2021-03-11T01:41:24Z-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-06-18-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00253-019-09699-x-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/190322-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/190322-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCNPq: 134018/2016-8-
Descrição: dc.descriptionFAPERJ: 2011/17411-8-
Descrição: dc.descriptionProcesso FAPESP: 2014/17526-8-
Descrição: dc.descriptionCNPq: 470261/2012-9-
Descrição: dc.descriptionNatural rubber latex (NRL) is a natural polymer which has arisen large interest in the biomedical field, mostly, due to its ability to facilitate angiogenesis and therefore, tissue repair. Moxifloxacin (MXF) is a broad-spectrum antibiotic orally administrated. Considering the biological properties of the NRL and its ability to deliver a wide range of compounds, the present study aimed to develop a novel device for infected chronic wound treatment. MXF-loaded NRL was obtained by a casting method. The results demonstrated that the incorporation of MXF in NRL did not promote any molecular interaction, preserving the integrity of the compounds. The mechanical properties of the biomaterial did not show any significant change, indicating enough elasticity for dermal application. The microbiological assays confirmed the ability of the polymer to deliver the drug without influencing its pharmacological properties. Moreover, it has expressed activity against major bacterial strains presented in wound infections. Finally, the biomaterial shown biocompatibility from the in vitro study. Thus, the present work has shown that MXF-loaded NRL membrane is a promising biomaterial to infected wound treatment.-
Formato: dc.format4767-4778-
Idioma: dc.languageen-
Relação: dc.relationApplied Microbiology and Biotechnology-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectAntibiotic-
Palavras-chave: dc.subjectMoxifloxacin-
Palavras-chave: dc.subjectNatural rubber latex-
Palavras-chave: dc.subjectSkin infection-
Palavras-chave: dc.subjectWound healing-
Título: dc.titleNovel polymeric dressing to the treatment of infected chronic wound-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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