Central muscarinic and LPBN mechanisms on sodium intake

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorAnesio, Augusto-
Autor(es): dc.creatorBarbosa, Silas Pereira-
Autor(es): dc.creatorDe Luca, Laurival A.-
Autor(es): dc.creatorde Paula, Patrícia Maria-
Autor(es): dc.creatorColombari, Débora S.A.-
Autor(es): dc.creatorColombari, Eduardo-
Autor(es): dc.creatorAndrade, Carina A.F.-
Autor(es): dc.creatorMenani, José V.-
Data de aceite: dc.date.accessioned2021-03-11T01:40:11Z-
Data de disponibilização: dc.date.available2021-03-11T01:40:11Z-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.brainresbull.2018.10.011-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/189887-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/189887-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCentral cholinergic activation stimulates water intake, but also NaCl intake when the inhibitory mechanisms are blocked with injections of moxonidine (α2 adrenergic/imidazoline agonist) into the lateral parabrachial nucleus (LPBN). In the present study, we investigated the involvement of central M1 and M2 muscarinic receptors on NaCl intake induced by pilocarpine (non-selective muscarinic agonist) intraperitoneally combined with moxonidine into the LPBN or by muscimol (GABAA agonist) into the LPBN. Male Holtzman rats with stainless steel cannulas implanted bilaterally in the LPBN and in the lateral ventricle were used. Pirenzepine (M1 muscarinic antagonist, 1 nmol/1 μl) or methoctramine (M2 muscarinic antagonist, 50 nmol/1 μL) injected intracerebroventricularly (i.c.v.) reduced 0.3 M NaCl and water intake in rats treated with pilocarpine (0.1 mg/100 g of body weight) injected intraperitoneally combined with moxonidine (0.5 nmol/0.2 μL) into the LPBN. In rats treated with muscimol (0.5 nmol/0.2 μL) into the LPBN, methoctramine i.c.v. also reduced 0.3 M NaCl and water intake, however, pirenzepine produced no effect. The results suggest that M1 and M2 muscarinic receptors activate central pathways involved in the control of water and sodium intake that are under the influence of the LPBN inhibitory mechanisms.-
Formato: dc.format14-20-
Idioma: dc.languageen-
Relação: dc.relationBrain Research Bulletin-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectCholinergic-
Palavras-chave: dc.subjectMethoctramine-
Palavras-chave: dc.subjectNaCl intake-
Palavras-chave: dc.subjectParabrachial-
Palavras-chave: dc.subjectPirenzepine-
Palavras-chave: dc.subjectSodium appetite-
Título: dc.titleCentral muscarinic and LPBN mechanisms on sodium intake-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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