Annexin A1 peptide and endothelial cell-conditioned medium modulate cervical tumorigenesis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCardin, Laila Toniol-
Autor(es): dc.creatorPrates, Janesly-
Autor(es): dc.creatorda Cunha, Bianca Rodrigues-
Autor(es): dc.creatorTajara, Eloiza Helena-
Autor(es): dc.creatorOliani, Sonia Maria-
Autor(es): dc.creatorRodrigues-Lisoni, Flávia Cristina-
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Descrição: dc.descriptionCervical cancer is one of the leading causes of cancer death in women worldwide, and its tumorigenesis can be influenced by the microenvironment. The anti-inflammatory protein annexin A1 (ANXA1) has been reported to be associated with cancer progression and metastasis, suggesting that it plays a role in regulating tumour cell proliferation. Here, we examined the effect of the N-terminal peptide Ac2-26 of ANXA1 on the HaCaT cell line (normal) and HeLa cell line (cervical cancer) co-cultured with endothelium cell-conditioned medium (HMC). Treatment with Ac2-26 decreased proliferation and increased motility of cervical cancer cells, but did not affect cellular morphology or viability. Combined HMC stimulus and Ac2-26 treatment resulted in an increase in apoptotic HeLa cells, upregulated expression of MMP2, and downregulated expression of COX2, EP3 and EP4. In conclusion, Ac2-26 treatment may modulate cellular and molecular mechanisms underlying cervical carcinogenesis.-
Formato: dc.format668-681-
Idioma: dc.languageen-
Relação: dc.relationFEBS Open Bio-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectANXA1-
Palavras-chave: dc.subjectcarcinogenesis-
Palavras-chave: dc.subjectcervical cancer-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectpeptide treatment-
Título: dc.titleAnnexin A1 peptide and endothelial cell-conditioned medium modulate cervical tumorigenesis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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