HLA-G, -E and -F regulatory and coding region variability and haplotypes in the Beninese Toffin population sample

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSonon, Paulin-
Autor(es): dc.creatorSadissou, Ibrahim-
Autor(es): dc.creatorTokplonou, Léonidas-
Autor(es): dc.creatorM'po, Kuumaaté K.G.-
Autor(es): dc.creatorGlitho, Sonya S.C.-
Autor(es): dc.creatorAgniwo, Privat-
Autor(es): dc.creatorIbikounlé, Moudachirou-
Autor(es): dc.creatorMassaro, Juliana Doblas-
Autor(es): dc.creatorMassougbodji, Achille-
Autor(es): dc.creatorMoreau, Philippe-
Autor(es): dc.creatorSabbagh, Audrey-
Autor(es): dc.creatorMendes-Junior, Celso T.-
Autor(es): dc.creatorMoutairou, Kabirou A.-
Autor(es): dc.creatorCastelli, Erick C.-
Autor(es): dc.creatorCourtin, David-
Autor(es): dc.creatorDonadi, Eduardo A.-
Data de aceite: dc.date.accessioned2021-03-11T01:39:32Z-
Data de disponibilização: dc.date.available2021-03-11T01:39:32Z-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2018-12-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.molimm.2018.08.016-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/189672-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/189672-
Descrição: dc.descriptionHLA-G/E/F genes exhibit immunomodulatory properties and are expressed in placenta. Little attention has been devoted to the study of these genes in sub-Saharan African populations, which are yet the most diverse. To fill this gap, we evaluated the complete gene variability, approximately 5.1 kb for HLA-G (n = 149), 7.7 kb for HLA-E (n = 150) and 6.2 kb for HLA-F (n = 152) in the remote Beninese Toffin population, using massive parallel sequencing. Overall, 96, 37 and 68 variable sites were detected along the entire HLA-G, -E and -F, respectively, arranged into region-specific haplotypes; i.e., promoter haplotypes (16, 19, and 15 respectively), coding haplotypes (19, 15, and 29 respectively), 3’ untranslated region (3′UTR) haplotypes (12, 7 and 2, respectively) and extended haplotypes (33, 31 and 32 respectively). All promoter/coding/3'UTR haplotypes followed the patterns already described in worldwide populations. HLA-E was the most conserved, exhibiting mainly two full-length encoded-molecules (E*01:01 and E*01:03), followed by HLA-F, three full-length proteins (F*01:01, F*01:02 and F*01:03) and HLA-G, four proteins: three full-length (G*01:01, G*01:03 and G*01:04) and one truncated (G*01:05N). Although HLA-G/E/F alleles in the Toffin population were the most frequently observed worldwide, the frequencies of the coding haplotypes were closely similar to those described for other African populations (Guinea-Conakry and Burkina-Faso), when compared to non-African ones (Brazilian), indicating that variable sites along these genes were present in Africa before human dispersion.-
Formato: dc.format108-127-
Idioma: dc.languageen-
Relação: dc.relationMolecular Immunology-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectAfrican-
Palavras-chave: dc.subjectHaplotypes-
Palavras-chave: dc.subjectHLA-E-
Palavras-chave: dc.subjectHLA-F-
Palavras-chave: dc.subjectHLA-G-
Palavras-chave: dc.subjectMassive parallel sequencing-
Título: dc.titleHLA-G, -E and -F regulatory and coding region variability and haplotypes in the Beninese Toffin population sample-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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