Dietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanisms

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorda Cruz, Raquel Santana-
Autor(es): dc.creatorAndrade, Fabia de Oliveira-
Autor(es): dc.creatorCarioni, Vivian Montes de Oca-
Autor(es): dc.creatorRosim, Mariana Papaléo-
Autor(es): dc.creatorMiranda, Mayara Lilian Paulino-
Autor(es): dc.creatorFontelles, Camile Castilho-
Autor(es): dc.creatorde Oliveira, Pedro Vitoriano-
Autor(es): dc.creatorBarbisan, Luis Fernando-
Autor(es): dc.creatorCastro, Inar Alves-
Autor(es): dc.creatorOng, Thomas Prates-
Data de aceite: dc.date.accessioned2021-03-11T01:39:29Z-
Data de disponibilização: dc.date.available2021-03-11T01:39:29Z-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.fct.2019.110813-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/189658-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/189658-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionProcesso FAPESP: 11/23259-4-
Descrição: dc.descriptionProcesso FAPESP: 2013/04960-9-
Descrição: dc.descriptionCNPq: 307910/2016-4-
Descrição: dc.descriptionZinc is required for fetal development and is involved in key processes associated with breast carcinogenesis. We evaluated whether maternal zinc deficiency or supplementation during gestation influences female offspring susceptibility to breast cancer in adulthood. C57BL/6 mice consumed during gestation control (30 p.p.m. zinc), zinc-deficient (8 p.p.m) or zinc-supplemented (45 p.p.m.) diets. Maternal zinc supplementation increased in female mice offspring the incidence of chemically-induced mammary adenocarcinomas that were heavier, compared to control group. This was accompanied by a decreased number of terminal end buds, increased cell proliferation and apoptosis, and increased tumor suppressors p21, p53 and Rassf1, Zfp382 and Stat3 expression in mammary glands, as well as increased zinc status. Although maternal zinc deficiency did not alter the incidence of these lesions, it also induced heavier mammary adenocarcinomas, compared to control group. These effects were accompanied by a decreased number of terminal end buds, increased proto-oncogenes c-Myc and Lmo4 expression and H3K9Me3 and H4K20Me3 epigenetic marks in mammary glands of offspring, and decreased zinc status and increased levels of oxidative marker malondialdehyde. The data suggest that both maternal zinc deficiency and supplementation during gestation programmed increased breast cancer susceptibility in adult mice offspring following a J-shaped pattern through distinct mechanisms.-
Idioma: dc.languageen-
Relação: dc.relationFood and Chemical Toxicology-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectBreast cancer-
Palavras-chave: dc.subjectFetal programming-
Palavras-chave: dc.subjectGestation-
Palavras-chave: dc.subjectMaternal nutrition-
Palavras-chave: dc.subjectZinc-
Título: dc.titleDietary zinc deficiency or supplementation during gestation increases breast cancer susceptibility in adult female mice offspring following a J-shaped pattern and through distinct mechanisms-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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