Paracoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMarcos, Caroline Maria-
Autor(es): dc.creatorde Oliveira, Haroldo Cesar-
Autor(es): dc.creatorAssato, Patricia Akemi-
Autor(es): dc.creatorde Andrade, Cleverton Roberto-
Autor(es): dc.creatorFusco-Almeida, Ana Marisa-
Autor(es): dc.creatorMendes-Giannini, Maria José Soares-
Data de aceite: dc.date.accessioned2021-03-11T01:39:28Z-
Data de disponibilização: dc.date.available2021-03-11T01:39:28Z-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1093/mmy/myy112-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/189646-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/189646-
Descrição: dc.descriptionThe Paracoccidioides brasiliensis strain downregulated the expression of adhesin Pb14-3-3 (Pb14-3-3 aRNA) was evaluated in a murine model of paracoccidioidomycosis (PCM). Pb14-3-3 aRNA displays attenuated virulence and triggered the formation of fewer granulomas by lowering the fungal burden in the lungs. Additionally, the Pb14-3-3 aRNA showed more elongated yeast cells and less ability to induce pneumocytes apoptosis in vitro. Our results show that 14-3-3 is an important virulence factor in P. brasiliensis-induced pulmonary infection.-
Formato: dc.format900-904-
Idioma: dc.languageen-
Relação: dc.relationMedical mycology-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectParacoccidioides brasiliensis: 14-3-3 protein-
Palavras-chave: dc.subjectpneumocytes apoptosis-
Palavras-chave: dc.subjectvirulence in murine model-
Título: dc.titleParacoccidioides brasiliensis 14-3-3 protein is important for virulence in a murine model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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