Modulation of the endogenous Annexin A1 in a cigarette smoke cessation model: Potential therapeutic target in reversing the damage caused by smoking?

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorLebron, Isabella de Souza Lima-
Autor(es): dc.creatorda Silva, Ligia Furlan-
Autor(es): dc.creatorPaletta, Julia Tagliaferri-
Autor(es): dc.creatorda Silva, Rafael André-
Autor(es): dc.creatorSant'Ana, Monielle-
Autor(es): dc.creatorCosta, Sara de Souza-
Autor(es): dc.creatorIyomasa-Pilon, Melina Mizusaki-
Autor(es): dc.creatorSouza, Helena Ribeiro-
Autor(es): dc.creatorPossebon, L.-
Autor(es): dc.creatorGirol, Ana Paula-
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Descrição: dc.descriptionBackground: Smoking cessation may help in the reversal of inflammation and damage caused by smoking. The endogenous annexin A1 (AnxA1) protein has anti-inflammatory effects which instigates the understanding of its role in the attenuation of inflammatory processes caused by smoking. Material and methods: Wistar rats were exposed to cigarette smoke for 8 weeks. After the exposure period, one of the groups remained other 8 weeks in the absence of smoke. Animals not exposed to smoke were used as control. Blood, trachea and lungs were obtained for histopathological, immunohistochemical and biochemical analyses. Results: Loss of cilia of the tracheal lining epithelium was found by smoke exposure, but smoking cessation led to recovery of the tracheal epithelium. Similarly, chronically exposed-to-smoke animals showed increased lymphocytes and macrophages in bronchoalveolar lavage and higher levels of glucose and gamma-GT in their blood. Reduction of lymphocytes, glucose and gamma-GT occurred after smoking cessation. In addition, IL-1β, IL-6, IL-10, TNF-α and MCP-1 levels were elevated by smoke exposure. Smoking cessation significantly reduced the levels of IL-1β, IL-6 and MCP-1 but increased the IL-10 concentration. Numerous mast cells and macrophages were observed in the lung of chronically exposed-to-smoke animals with reduction by smoking cigarette abstinence. AnxA1 increased expression and concomitant NF-κB reduction were found in the smoking cessation group. Conclusion: Our results showed that cigarette abstinence promoted partial recovery of the inflammatory process. The attenuation of the inflammatory profile may be associated with the overexpression of AnxA1 protein.-
Idioma: dc.languageen-
Relação: dc.relationPathology Research and Practice-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectAnnexin A1-
Palavras-chave: dc.subjectCOPD-
Palavras-chave: dc.subjectInflammatory mediators-
Palavras-chave: dc.subjectTabagism-
Título: dc.titleModulation of the endogenous Annexin A1 in a cigarette smoke cessation model: Potential therapeutic target in reversing the damage caused by smoking?-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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