Botryane terpenoids produced by Nemania bipapillata, an endophytic fungus isolated from red alga Asparagopsis taxiformis - Falkenbergia stage

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMedina, Rebeca P.-
Autor(es): dc.creatorAraujo, Angela R.-
Autor(es): dc.creatorBatista, João M.-
Autor(es): dc.creatorCardoso, Carmen L.-
Autor(es): dc.creatorSeidl, Cláudia-
Autor(es): dc.creatorVilela, Adriana F. L.-
Autor(es): dc.creatorDomingos, Helori V.-
Autor(es): dc.creatorCosta-Lotufo, Leticia V.-
Autor(es): dc.creatorAndersen, Raymond J.-
Autor(es): dc.creatorSilva, Dulce H. S.-
Data de aceite: dc.date.accessioned2021-03-11T01:39:16Z-
Data de disponibilização: dc.date.available2021-03-11T01:39:16Z-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-019-48655-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/189570-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/189570-
Descrição: dc.descriptionA chemical study of the EtOAc extract of Nemania bipapillata (AT-05), an endophytic fungus isolated from the marine red alga Asparagopsis taxiformis - Falkenbergia stage, led to the isolation of five new botryane sesquiterpenes, including the diastereomeric pair (+)-(2R,4S,5R,8S)-(1) and (+)-(2R,4R,5R,8S)-4-deacetyl-5-hydroxy-botryenalol (2), (+)-(2R,4S,5R,8R)-4-deacetyl-botryenalol (3), one pair of diastereomeric botryane norsesquiterpenes bearing an unprecedented degraded carbon skeleton, (+)-(2R,4R,8R)-(4) and (+)-(2R,4S,8S)-(5), which were named nemenonediol A and nemenonediol B, respectively, in addition to the known 4β-acetoxy-9β,10β,15α-trihydroxyprobotrydial (6). Their structures were elucidated using 1D and 2D NMR, HRESIMS and comparison with literature data of similar known compounds. The absolute configurations of 2, 3 and 4 were deduced by comparison of experimental and calculated electronic circular dichroism (ECD) spectra, while those of 1 and 5 were assigned from vibrational circular dichroism (VCD) data. Compound 4 weakly inhibited acetylcholinesterase, whereas compound 1 inhibited both acetylcholinesterase and butyrylcholinesterase. Compounds 1, 3, 5 and 6 were tested against two carcinoma cell lines (MCF-7 and HCT-116), but showed no significant citotoxicity at tested concentrations (IC50 > 50 µM).-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
Direitos: dc.rightsopenAccess-
Título: dc.titleBotryane terpenoids produced by Nemania bipapillata, an endophytic fungus isolated from red alga Asparagopsis taxiformis - Falkenbergia stage-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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