Evaluation of osteoconduction of biphasic calcium phosphate ceramic in the calvaria of rats: Microscopic and histometric analysis

Registro completo de metadados
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDe Oliveira Puttini, Igor-
Autor(es): dc.creatorPoli, Pier Paolo-
Autor(es): dc.creatorMaiorana, Carlo-
Autor(es): dc.creatorDe Vasconcelos, Igor Rodrigues-
Autor(es): dc.creatorSchmidt, Luis Eduardo-
Autor(es): dc.creatorColombo, Luara Teixeira-
Autor(es): dc.creatorHadad, Henrique-
Autor(es): dc.creatorDos Santos, Gabriel Mulinari-
Autor(es): dc.creatorDe Carvalho, Paulo Sergio Perri-
Autor(es): dc.creatorSouza, Francisley Ávila-
Data de aceite: dc.date.accessioned2021-03-11T01:38:20Z-
Data de disponibilização: dc.date.available2021-03-11T01:38:20Z-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-10-06-
Data de envio: dc.date.issued2019-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jfb10010007-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/189237-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/189237-
Descrição: dc.description(1) Background: Evaluate the osteoconduction capability of a biphasic calcium phosphate (BCP) ceramic composed of hydroxyapatite and β-tricalcium phosphate 60%/40% in a rat model. (2) Methods: In the calvarial bone of 54 adult male rats, 7-mm diameter critical size defects were performed. The animals were randomly allocated to three experimental groups according to the type of material: blood clot (BCG), blood clot covered with a bovine-derived collagen membrane (MBCG), and BCP ceramic covered with a bovine-derived collagen membrane (BCPG). In each group, 6 animals were euthanatized at post-operative days 7, 30, and 60 for histological and histometric analysis. (3) Results: The qualitative analysis revealed the persistence of the collagen membrane at seven days, with no relevant newly bone formation in all groups. At 30 days, centripetal bone formation was observed residual particles of the biomaterial surrounded by fibroblasts noted in the BCPG. At 60 days, while BCG and MBCG showed a partial maturation with the central part of the defect populated by a fibrous connective tissue, in the BCPG the critical area was entirely occupied by newly formed bone. In the intra groups analysis was noted a significant increase in new bone formation during the experimental period (p < 0.05). At 60 days, BCPG showed a higher percentage area of new bone formation (p < 0.05). (4) Conclusion: BCP promoted a new bone formation by osteoconduction and might be considered a valid alternative in bone regeneration procedures.-
Idioma: dc.languageen-
Relação: dc.relationJournal of Functional Biomaterials-
Direitos: dc.rightsopenAccess-
Palavras-chave: dc.subjectBiphasic calcium phosphate-
Palavras-chave: dc.subjectBone regeneration-
Palavras-chave: dc.subjectBone substitute-
Palavras-chave: dc.subjectCeramics-
Título: dc.titleEvaluation of osteoconduction of biphasic calcium phosphate ceramic in the calvaria of rats: Microscopic and histometric analysis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.